dc.contributor.author | Pérez-Tanoira, Ramón | |
dc.contributor.author | Del Palacio Tamarit, Marta | |
dc.contributor.author | Vicente Montaña, Ana María | |
dc.contributor.author | Carmena, David | |
dc.contributor.author | Köster, Pamela Carolina | |
dc.contributor.author | Górgolas, Miguel | |
dc.contributor.author | Fortes Alen, José R | |
dc.contributor.author | Cabello-Úbeda, Alfonso | |
dc.contributor.author | Prieto-Pérez, Laura | |
dc.date.accessioned | 2023-07-17T10:46:54Z | |
dc.date.available | 2023-07-17T10:46:54Z | |
dc.date.issued | 2023-04-26 | |
dc.identifier.citation | Trop Med Infect Dis. 2023 Apr 26;8(5):250. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/16268 | |
dc.description.abstract | Human intestinal spirochetosis (HIS) can cause gastrointestinal symptoms, although asymptomatic infections have been described. Individuals from low-income countries, people living with HIV, and men who have sex with men (MSM) show increased risk. A retrospective review of all patients diagnosed with HIS (n = 165) between January 2013 and October 2020 at a tertiary hospital in Madrid, Spain, was performed to assess risk factors for symptomatic HIS, symptoms, and response to treatment. Most patients were male (n = 156; 94.5%), 86.7% were MSM, and 23.5% practiced chemsex, of whom most were symptomatic (p = 0.039). Most patients (78.4%) reported unprotected oral-anal intercourse. A total of 124 (81.1%) were symptomatic; diarrhea was the most common complaint (68.3%). Multivariable regression showed increased odds of symptoms associated with age under 41 (odds ratio 5.44, 95% CI 1.87-15.88; p = 0.002). Colonoscopy was normal in 153 (92.7%). Furthermore, 66.7% presented previous or concomitant sexually transmitted diseases (STDs). Among the patients, 102 underwent testing for other gastrointestinal pathogens, with positive results in 20 (19.6%). All symptomatic patients without concomitant gastrointestinal infection presenting improvement on follow-up (42 of 53) had received either metronidazole or doxycycline (p = 0.049). HIS should be considered as a cause of chronic diarrhea in MSM with high-risk sexual behavior after other causes have been ruled out; treatment with metronidazole is recommended. Coinfection with other STDs is common. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Intestinal spirochetosis | es_ES |
dc.subject | Diarrhea | es_ES |
dc.subject | Brachyspira | es_ES |
dc.subject | MSM | es_ES |
dc.subject | Chemsex | es_ES |
dc.subject | HIV infection | es_ES |
dc.subject | Histopathology | es_ES |
dc.subject | Metronidazole | es_ES |
dc.title | Increased Prevalence of Symptomatic Human Intestinal Spirochetosis in MSM with High-Risk Sexual Behavior in a Cohort of 165 Individuals | es_ES |
dc.type | research article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 37235298 | es_ES |
dc.format.volume | 8 | es_ES |
dc.format.number | 5 | es_ES |
dc.format.page | 250 | es_ES |
dc.identifier.doi | 10.3390/tropicalmed8050250 | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2414-6366 | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/tropicalmed8050250 | es_ES |
dc.identifier.journal | Tropical medicine and infectious disease | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |