Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/16038
Heat inactivated mycobacteria, alpha-Gal and zebrafish: Insights gained from experiences with two promising trained immunity inductors and a validated animal model
Immunology. 2022 Oct;167(2):139-153.
Trained immunity (TRAIM) may be defined as a form of memory where innate immune cells such as monocytes, macrophages, dendritic and natural killer (NK) cells undergo an epigenetic reprogramming that enhances their primary defensive capabilities. Cross-pathogen protective TRAIM can be triggered in different hosts by exposure to live microbes or microbe-derived products such as heat-inactivated Mycobacterium bovis or with the glycan α-Gal to elicit protective responses against several pathogens. We review the TRAIM paradigm using two models representing distinct scales of immune sensitization: the whole bacterial cell and one of its building blocks, the polysaccharides or glycans. Observations point out to macrophage lytic capabilities and cytokine regulation as two key components in non-specific innate immune responses against infections. The study of the TRAIM response deserves attention to better characterize the evolution of host-pathogen cooperation both for identifying the aetiology of some diseases and for finding new therapeutic strategies. In this field, the zebrafish provides a convenient and complete biological system that could help to deepen in the knowledge of TRAIM-mediated mechanisms in pathogen-host interactions.
Cross-protection | Glycan alpha-Gal | Heat-inactivated Mycobacterium bovis | Macrophages | Trained innate immunity
Mycobacterium Infections | Mycobacterium bovis | Animals | Cytokines | Disease Models, Animal | Hot Temperature | Immunity, Innate | Polysaccharides | Zebrafish
Files in this item
- HeatInactivatedMycobacteriaAlp ...