Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/16022
Título
Pertactin-Deficient Bordetella pertussis with Unusual Mechanism of Pertactin Disruption, Spain, 1986-2018
Autor(es)
Mir-Cros, Alba | Moreno-Mingorance, Albert | Martín-Gómez, M Teresa | Abad, Raquel ISCIII | Bloise, Iván | Campins, Magda | González-Praetorius, Alejandro | Gutiérrez, M Nieves | Martín-González, Héctor | Muñoz-Almagro, Carmen | Orellana, M Ángeles | de Pablos, Manuela | Roca-Grande, Josep | Rodrigo, Carlos | Rodríguez, M Elena | Uriona, Sonia | Vidal, M José | Pumarola, Tomàs | Larrosa, M Nieves | González-López, Juan José
Fecha de publicación
2022-05
Cita
Emerg Infect Dis. 2022 May;28(5):967-976.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Bordetella pertussis not expressing pertactin has increased in countries using acellular pertussis vaccines (ACV). The deficiency is mostly caused by pertactin gene disruption by IS481. To assess the effect of the transition from whole-cell vaccine to ACV on the emergence of B. pertussis not expressing pertactin in Spain, we studied 342 isolates collected during 1986-2018. We identified 93 pertactin-deficient isolates. All were detected after introduction of ACV and represented 38% of isolates collected during the ACV period; 58.1% belonged to a genetic cluster of isolates carrying the unusual prn::del(-292, 1340) mutation. Pertactin inactivation by IS481 insertion was identified in 23.7% of pertactin-deficient isolates, arising independently multiple times and in different phylogenetic branches. Our findings support the emergence and dissemination of a cluster of B. pertussis with an infrequent mechanism of pertactin disruption in Spain, probably resulting from introduction of ACV.
Palabras clave
Bordetella pertussis | Spain | Bacteria | Pertussis vaccine | Phylogenetic evolution | Virulence factors | Whooping cough
MESH
Bordetella pertussis | Whooping Cough | Bacterial Outer Membrane Proteins | Humans | Pertussis Vaccine | Phylogeny | Spain | Virulence Factors, Bordetella
Versión en línea
DOI
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