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dc.contributor.author | Sánchez-Busó, Leonor | |
dc.contributor.author | Cole, Michelle J | |
dc.contributor.author | Spiteri, Gianfranco | |
dc.contributor.author | Day, Michaela | |
dc.contributor.author | Jacobsson, Susanne | |
dc.contributor.author | Golparian, Daniel | |
dc.contributor.author | Sajedi, Noshin | |
dc.contributor.author | Yeats, Corin A | |
dc.contributor.author | Abudahab, Khalil | |
dc.contributor.author | Underwood, Anthony | |
dc.contributor.author | Bluemel, Benjamin | |
dc.contributor.author | Aanensen, David M | |
dc.contributor.author | Unemo, Magnus | |
dc.contributor.author | Centre for Genomic Pathogen Surveillance | |
dc.contributor.author | Euro-GASP study group | |
dc.contributor.author | Vazquez-Moreno, Julio Alberto | |
dc.contributor.author | Diaz Franco, Asuncion | |
dc.contributor.author | Abad, Raquel | |
dc.date.accessioned | 2023-05-05T11:19:12Z | |
dc.date.available | 2023-05-05T11:19:12Z | |
dc.date.issued | 2022-06 | |
dc.identifier.citation | Lancet Microbe. 2022 Jun;3(6):e452-e463. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15989 | |
dc.description.abstract | Background: Genomic surveillance using quality-assured whole-genome sequencing (WGS) together with epidemiological and antimicrobial resistance (AMR) data is essential to characterise the circulating Neisseria gonorrhoeae lineages and their association to patient groups (defined by demographic and epidemiological factors). In 2013, the European gonococcal population was characterised genomically for the first time. We describe the European gonococcal population in 2018 and identify emerging or vanishing lineages associated with AMR and epidemiological characteristics of patients, to elucidate recent changes in AMR and gonorrhoea epidemiology in Europe. Methods: We did WGS on 2375 gonococcal isolates from 2018 (mainly Sept 1-Nov 30) in 26 EU and EEA countries. Molecular typing and AMR determinants were extracted from quality-checked genomic data. Association analyses identified links between genomic lineages, AMR, and epidemiological data. Findings: Azithromycin-resistant N gonorrhoeae (8·0% [191/2375] in 2018) is rising in Europe due to the introduction or emergence and subsequent expansion of a novel N gonorrhoeae multi-antigen sequence typing (NG-MAST) genogroup, G12302 (132 [5·6%] of 2375; N gonorrhoeae sequence typing for antimicrobial resistance [NG-STAR] clonal complex [CC]168/63), carrying a mosaic mtrR promoter and mtrD sequence and found in 24 countries in 2018. CC63 was associated with pharyngeal infections in men who have sex with men. Susceptibility to ceftriaxone and cefixime is increasing, as the resistance-associated lineage, NG-MAST G1407 (51 [2·1%] of 2375), is progressively vanishing since 2009-10. Interpretation: Enhanced gonococcal AMR surveillance is imperative worldwide. WGS, linked to epidemiological and AMR data, is essential to elucidate the dynamics in gonorrhoea epidemiology and gonococcal populations as well as to predict AMR. When feasible, WGS should supplement the national and international AMR surveillance programmes to elucidate AMR changes over time. In the EU and EEA, increasing low-level azithromycin resistance could threaten the recommended ceftriaxone-azithromycin dual therapy, and an evidence-based clinical azithromycin resistance breakpoint is needed. Nevertheless, increasing ceftriaxone susceptibility, declining cefixime resistance, and absence of known resistance mutations for new treatments (zoliflodacin, gepotidacin) are promising. | es_ES |
dc.description.sponsorship | This study was supported by the European Centre for Disease Prevention and Control, the Centre for Genomic Pathogen Surveillance, the Li Ka Shing Foundation (Big Data Institute, University of Oxford), the Wellcome Genome Campus, the Foundation for Medical Research at Örebro University Hospital, and grants from Wellcome (098051 and 099202). LSB was funded by Conselleria de Sanitat Universal i Salut Pública, Generalitat Valenciana (Plan GenT CDEI-06/20-B), Valencia, Spain, and Ministry of Science, Innovation and Universities (PID2020–120113RA-I00), Spain, at the time of analysing and writing this manuscript. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Gonorrhea | es_ES |
dc.subject.mesh | Sexual and Gender Minorities | es_ES |
dc.subject.mesh | Anti-Bacterial Agents | es_ES |
dc.subject.mesh | Azithromycin | es_ES |
dc.subject.mesh | Cefixime | es_ES |
dc.subject.mesh | Ceftriaxone | es_ES |
dc.subject.mesh | Drug Resistance, Bacterial | es_ES |
dc.subject.mesh | Europe | es_ES |
dc.subject.mesh | Genomics | es_ES |
dc.subject.mesh | Homosexuality, Male | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Microbial Sensitivity Tests | es_ES |
dc.subject.mesh | Neisseria gonorrhoeae | es_ES |
dc.title | Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 35659907 | es_ES |
dc.format.volume | 3 | es_ES |
dc.format.number | 6 | es_ES |
dc.format.page | e452-e463 | es_ES |
dc.identifier.doi | 10.1016/S2666-5247(22)00044-1 | es_ES |
dc.contributor.funder | Unión Europea. European Centre for Disease Prevention and Control (ECDC) | es_ES |
dc.contributor.funder | Centre for Genomic Pathogen Surveillance | es_ES |
dc.contributor.funder | Li Ka Shing Foundation | es_ES |
dc.contributor.funder | Generalitat Valenciana (España) | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | es_ES |
dc.contributor.funder | Örebro University Hospital (Suecia) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2666-5247 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/S2666-5247(22)00044-1 | es_ES |
dc.identifier.journal | The Lancet. Microbe | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2020-120113RA-I00 | es_ES |