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dc.contributor.author | Sevilla-Movilla, Silvia | |
dc.contributor.author | Fuentes, Patricia | |
dc.contributor.author | Rodríguez-García, Yaiza | |
dc.contributor.author | Arellano-Sánchez, Nohemi | |
dc.contributor.author | Krenn, Peter W | |
dc.contributor.author | de Val, Soledad Isern | |
dc.contributor.author | Montero-Herradón, Sara | |
dc.contributor.author | García-Ceca, Javier | |
dc.contributor.author | Burdiel-Herencia, Valeria | |
dc.contributor.author | Gardeta, Sofía R | |
dc.contributor.author | Aguilera-Montilla, Noemí | |
dc.contributor.author | Barrio-Alonso, Celia | |
dc.contributor.author | Crainiciuc, Georgiana | |
dc.contributor.author | Bouvard, Daniel | |
dc.contributor.author | García-Pardo, Angeles | |
dc.contributor.author | Zapata, Agustin G | |
dc.contributor.author | Hidalgo, Andres | |
dc.contributor.author | Fässler, Reinhard | |
dc.contributor.author | Carrasco, Yolanda R | |
dc.contributor.author | Toribio, Maria L | |
dc.contributor.author | Teixidó, Joaquin | |
dc.date.accessioned | 2023-04-03T11:35:03Z | |
dc.date.available | 2023-04-03T11:35:03Z | |
dc.date.issued | 2022-08 | |
dc.identifier.citation | Eur J Immunol. 2022 Aug;52(8):1228-1242 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15732 | |
dc.description.abstract | ICAP-1 regulates β1-integrin activation and cell adhesion. Here, we used ICAP-1-null mice to study ICAP-1 potential involvement during immune cell development and function. Integrin α4β1-dependent adhesion was comparable between ICAP-1-null and control thymocytes, but lack of ICAP-1 caused a defective single-positive (SP) CD8+ cell generation, thus, unveiling an ICAP-1 involvement in SP thymocyte development. ICAP-1 bears a nuclear localization signal and we found it displayed a strong nuclear distribution in thymocytes. Interestingly, there was a direct correlation between the lack of ICAP-1 and reduced levels in SP CD8+ thymocytes of Runx3, a transcription factor required for CD8+ thymocyte generation. In the spleen, ICAP-1 was found evenly distributed between cytoplasm and nuclear fractions, and ICAP-1-/- spleen T and B cells displayed upregulation of α4β1-mediated adhesion, indicating that ICAP-1 negatively controls their attachment. Furthermore, CD3+ - and CD19+ -selected spleen cells from ICAP-1-null mice showed reduced proliferation in response to T- and B-cell stimuli, respectively. Finally, loss of ICAP-1 caused a remarkable decrease in marginal zone B- cell frequencies and a moderate increase in follicular B cells. Together, these data unravel an ICAP-1 involvement in the generation of SP CD8+ thymocytes and in the control of marginal zone B-cell numbers. | es_ES |
dc.description.sponsorship | This work was supported by grants SAF2017- 85146-R and PID2020-116291RB-I00 from the Ministerio de Ciencia e Innovación (MICINN) to J.T., PID2019-105623RB-I00 from MICINN to M.L.T., BFU2013-48828-P from MICINN to Y.R.C., ERC Synergy Grant (2018) to R.F., RTI2018-095497-B-I00 from MICINN to A.H, and RTI2018-093938-B-I100 from MICINN, and (RD16/0011/0002, TERCEL) from Instituto de Salud Carlos III to A.G.Z. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Adaptor Proteins, Signal Transducing | es_ES |
dc.subject.mesh | B-Lymphocytes | es_ES |
dc.subject.mesh | CD8-Positive T-Lymphocytes | es_ES |
dc.subject.mesh | Lymphocyte Activation | es_ES |
dc.subject.mesh | Thymocytes | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Cell Differentiation | es_ES |
dc.subject.mesh | Integrin beta1 | es_ES |
dc.subject.mesh | Mice | es_ES |
dc.subject.mesh | Mice, Knockout | es_ES |
dc.subject.mesh | Spleen | es_ES |
dc.subject.mesh | Thymus Gland | es_ES |
dc.title | ICAP-1 loss impairs CD8+ thymocyte development and leads to reduced marginal zone B cells in mice. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 35491946 | es_ES |
dc.format.volume | 52 | es_ES |
dc.format.number | 8 | es_ES |
dc.format.page | 1228 | es_ES |
dc.identifier.doi | 10.1002/eji.202149560 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1521-4141 | es_ES |
dc.relation.publisherversion | 10.1002/eji.202149560 | es_ES |
dc.identifier.journal | European journal of immunology | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmune | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SAF2017-85146-R | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2020-116291RB-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PID2019-105623RB-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/BFU2013-48828-P | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-095497-B-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-093938-B-I100 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RD16/0011/0002 | es_ES |