Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15479
Título
CCR5 deficiency predisposes to fatal outcome in influenza virus infection
Autor(es)
Falcon, A | Cuevas, Maria Teresa ISCIII | Rodriguez-Frandsen, A | Reyes, Noelia ISCIII | Pozo Sanchez, Francisco ISCIII | Moreno, Silvia ISCIII | Ledesma, Juan ISCIII | Martínez-Alarcón, J | Nieto, A | Casas Flecha, Inmaculada ISCIII
Fecha de publicación
2015-08
Cita
J Gen Virol. 2015 Aug;96(8):2074-2078.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Influenza epidemics affect all age groups, although children, the elderly and those with underlying medical conditions are the most severely affected. Whereas co-morbidities are present in 50% of fatal cases, 25-50% of deaths are in apparently healthy individuals. This suggests underlying genetic determinants that govern infection severity. Although some viral factors that contribute to influenza disease are known, the role of host genetic factors remains undetermined. Data for small cohorts of influenza-infected patients are contradictory regarding the potential role of chemokine receptor 5 deficiency (CCR5-Δ32 mutation, a 32 bp deletion in the CCR5 gene) in the outcome of influenza virus infection. We tested 171 respiratory samples from influenza patients (2009 pandemic) for CCR5-Δ32 and evaluated its correlation with patient mortality. CCR5-Δ32 patients (17.4%) showed a higher mortality rate than WT individuals (4.7%; P = 0.021), which indicates that CCR5-Δ32 patients are at higher risk than the normal population of a fatal outcome in influenza infection.
MESH
Adolescent | Adult | Aged | Child | Female | Gene Deletion | Genetic Predisposition to Disease | Genotype | Humans | Influenza A Virus, H1N1 Subtype | Influenza, Human | Male | Middle Aged | Receptors, CCR5 | Young Adult
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