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dc.contributor.author | Sainz, Talía | |
dc.contributor.author | Casas Flecha, Inmaculada | |
dc.contributor.author | González-Esguevillas, Mónica | |
dc.contributor.author | Escosa-Garcia, Luis | |
dc.contributor.author | Muñoz-Fernández, María Ángeles | |
dc.contributor.author | Prieto, Luis | |
dc.contributor.author | Gosalbes, María José | |
dc.contributor.author | Jiménez-Hernández, Nuria | |
dc.contributor.author | Ramos, José Tomas | |
dc.contributor.author | Navarro, María Luisa | |
dc.contributor.author | Mellado, María José | |
dc.contributor.author | Serrano-Villar, Sergio | |
dc.contributor.author | Calvo, Cristina | |
dc.date.accessioned | 2022-12-20T11:30:16Z | |
dc.date.available | 2022-12-20T11:30:16Z | |
dc.date.issued | 2022-07-19 | |
dc.identifier.citation | Front Pediatr. 2022 Jul 19;10:919753. | es_ES |
dc.identifier.issn | 2296-2360 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15291 | |
dc.description | Final results of this work have been presented at the following meetings: 36rd Annual Meeting of the European Society for Pediatric Infectious Diseases (ESPID 2018), Malmö, Sweden, 28th May-June 2nd, 2018. (Ref. ESP18-0517). | es_ES |
dc.description.abstract | Aims: Vaccine response is poor among children living with HIV. The gut microbiota has been identified as a potential target to improve vaccine immunogenicity, but data are scarce in the context of HIV infection. Methods: Pilot, double-blind, randomized placebo-controlled trial in which 24 HIV-infected children were randomized to receive a mixture of symbiotics, omega-3/6 fatty acids, and amino acids or placebo for 4 weeks, each in combination with ART, and were then immunized against influenza. Vaccine response and safety of the nutritional supplementation were the primary outcomes. Results: Eighteen HIV-infected children completed the follow-up period (mean age 11.5 ± 4.14 years, 61% female). The nutritional supplement was safe but did not enhance the response to the influenza vaccine. A 4-fold rise in antibody titers was obtained in only 37.5% of participants in the intervention arm vs. 40% in the placebo. No immunological or inflammatory predictors of vaccine response were identified. Conclusions: In this exploratory study, a 4-week course of symbiotics did not increase influenza vaccine immunogenicity in HIV-infected children. Larger studies are warranted to address the potential of modulating the microbiome in children living with HIV. | es_ES |
dc.description.sponsorship | This work was funded by the Instituto de Salud Carlos III-Fondos FEDER (grant number CB21/17/00025), Acción Estratégica en Salud (PI13/0422, PI17/01283, PI18/00154, and PI18CIII/00009). TS and SS-V have been funded by the Instituto de Salud Carlos III-Fondos FEDER (BA21/00022 and BA21/00017). The funding bodies did not have a role in the design or conduct of the study, the analysis and interpretation of the results, and the writing of the report or the decision to publish. The authors would like to particularly acknowledge all the children and adolescents as well as their families for their participation in this study. They acknowledge the Spanish Pediatric HIV infection Group CORISPE and the Pediatric HIV BioBank integrated in the Spanish AIDS Research Network and collaborating Centers [supported by the Instituto de Salud Carlos III, Spanish Health Ministry (Grant n◦ RD06/0006/0035)] for its collaboration and cession of clinical information and samples used in this work. Nutricion Médica S.L., manufactured and packaged the nutritional product under investigation. Final results of this work have been presented at the following meetings: 36rd Annual Meeting of the European Society for Pediatric Infectious Diseases (ESPID 2018), Malmö, Sweden, 28th May-June 2nd, 2018. (Ref. ESP18-0517). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | HIV | es_ES |
dc.subject | Children | es_ES |
dc.subject | Immunoactivation | es_ES |
dc.subject | Influenza vaccine response | es_ES |
dc.subject | Microbiota | es_ES |
dc.title | Nutritional Supplementation to Increase Influenza Vaccine Response in Children Living With HIV: A Pilot Clinical Trial | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 35928688 | es_ES |
dc.format.volume | 10 | es_ES |
dc.format.page | 919753 | es_ES |
dc.identifier.doi | 10.3389/fped.2022.919753 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Red de Investigación Cooperativa en Investigación en Sida (España) | es_ES |
dc.contributor.funder | Ministerio de Sanidad (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.3389/fped.2022.919753 | es_ES |
dc.identifier.journal | Frontiers In Pediatrics | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RD06/0006/0035 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/CB21/17/00025 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI13/0422 | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/Subprograma Estatal de Generación de Conocimiento/PI17 - Proyectos de investigacion en salud (AES 2017). Modalidad proyectos en salud. (2017)/PI17/01283 | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/Subprograma Estatal de Generación de Conocimiento/PI18 - Proyectos de investigacion en salud (AES 2018). Modalidad proyectos en salud. (2018)/PI18/00154 | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/Subprograma Estatal de Generación de Conocimiento/PI18-ISCIII Modalidad Proyectos de Investigacion en Salud Intramurales. (2018)/PI18CIII/00009 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/BA21/00022 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/BA21/00017 | es_ES |