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dc.contributor.author | Jarabo, Patricia | |
dc.contributor.author | Barredo, Celia G | |
dc.contributor.author | de Pablo, Carmen | |
dc.contributor.author | Casas-Tinto, Sergio | |
dc.contributor.author | Martin, Francisco A | |
dc.date.accessioned | 2022-12-01T10:13:37Z | |
dc.date.available | 2022-12-01T10:13:37Z | |
dc.date.issued | 2022-06-30 | |
dc.identifier.citation | Commun Biol. 2022 Jun 30;5(1):644. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/15248 | |
dc.description.abstract | Virtually every single living organism on Earth shows a circadian (i.e. "approximately a day") internal rhythm that is coordinated with planet rotation (i.e. 24 hours). External cues synchronize the central clock of the organism. Consequences of biological rhythm disruptions have been extensively studied on cancer. Still, mechanisms underlying these alterations, and how they favor tumor development remain largely unknown. Here, we show that glioblastoma-induced neurodegeneration also causes circadian alterations in Drosophila. Preventing neurodegeneration in all neurons by genetic means reestablishes normal biological rhythms. Interestingly, in early stages of tumor development, the central pacemaker lengthens its period, whereas in later stages this is severely disrupted. The re-adjustment of the external light:dark period to longer glioblastoma-induced internal rhythms delays glioblastoma progression and ameliorates associated deleterious effects, even after the tumor onset. | es_ES |
dc.description.sponsorship | This work was supported by the Spanish Research Agency (MICINN) under the grant PGC2018-094630-B-I00 to S.C.T. and grant PGC2018-094630-B-100 to F.A.M., cofinanced by the European Regional Development Fund (ERDF). F.A.M. is a recipient of a Ramon y Cajal contract (2014-14961). C.G.B. is a recipient of a FPU predoctoral fellowship (FPU19/04449 -MEFP-). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Drosophila Proteins | es_ES |
dc.subject.mesh | Glioblastoma | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Circadian Rhythm | es_ES |
dc.subject.mesh | Cues | es_ES |
dc.subject.mesh | Drosophila | es_ES |
dc.title | Alignment between glioblastoma internal clock and environmental cues ameliorates survival in Drosophila | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 35773327 | es_ES |
dc.format.volume | 5 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 644 | es_ES |
dc.identifier.doi | 10.1038/s42003-022-03600-9 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2399-3642 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/s42003-022-03600-9 | es_ES |
dc.identifier.journal | Communications Biology | es_ES |
dc.repisalud.centro | ISCIII::Instituto de Investigación de Enfermedades Raras | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PGC2018-094630-B-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/FPU19/04449 |