Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15192
Título
Evaluation of the Thermal Stability of a Vaccine Prototype Based on Virus-like Particle Formulated HIV-1 Envelope
Autor(es)
Fecha de publicación
2022-03-22
Cita
Vaccines (Basel). 2022 Mar 22;10(4):484.
Idioma
Inglés
Tipo de documento
journal article
Resumen
The long-term storage stability of vaccines has a major impact on the roll-out and success of global immunization programs. For the Human Immunodeficiency Virus type 1 (HIV-1) virus-like particle (VLP) vaccine prototype evaluated here, nanoparticle tracking analysis (NTA), and enzyme-linked immunoabsorbent assay (ELISA) results demonstrated a remarkable structural stability. VLPs maintained their integrity and the recognition of relevant B-cell epitopes for three months at 4 and -20 °C. Interestingly, most particles remained intact and preserved the recognition of relevant epitopes even after a week of storage at room temperature.
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