Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/15149
Título
Effectiveness of complete primary vaccination against COVID-19 at primary care and community level during predominant Delta circulation in Europe: multicentre analysis, I-MOVE-COVID-19 and ECDC networks, July to August 2021
Autor(es)
Kissling, Esther | Hooiveld, Mariëtte | Martínez-Baz, Iván | Mazagatos, Clara ISCIII | William, Naoma | Vilcu, Ana-Maria | Kooijman, Marjolein N | Ilić, Maja | Domegan, Lisa | Machado, Ausenda | de Lusignan, Simon | Lazar, Mihaela | Meijer, Adam | Brytting, Mia | Casado, Itziar | Larrauri, Amparo ISCIII | Murray, Josephine-L K | Behillil, Sylvie | de Gier, Brechje | Mlinarić, Ivan | O'Donnell, Joan | Rodrigues, Ana Paula | Tsang, Ruby | Timnea, Olivia | de Lange, Marit | Riess, Maximilian | Castilla Catalán, Jesús | Pozo Sanchez, Francisco ISCIII | Hamilton, Mark | Falchi, Alessandra | Knol, Mirjam J | Kurečić Filipović, Sanja | Dunford, Linda | Guiomar, Raquel | Cogdale, Jade | Cherciu, Carmen | Jansen, Tessa | Enkirch, Theresa | Basile, Luca | Connell, Jeff | Gomez, Verónica | Sandonis-Martin, Virginia ISCIII | Bacci, Sabrina | Rose, Angela Mc | Pastore Celentano, Lucia | Valenciano, Marta | I-MOVE-COVID-19 | ECDC primary care study teams | Conde-San Román, Patricia ISCIII | Casas Flecha, Inmaculada ISCIII | Oliva Dominguez, Jesus Angel ISCIII | Delgado-Sanz, Concepcion ISCIII
Fecha de publicación
2022-05
Cita
Euro Surveill. 2022 May;27(21):2101104.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Introduction: In July and August 2021, the SARS-CoV-2 Delta variant dominated in Europe. Aim: Using a multicentre test-negative study, we measured COVID-19 vaccine effectiveness (VE) against symptomatic infection. Methods: Individuals with COVID-19 or acute respiratory symptoms at primary care/community level in 10 European countries were tested for SARS-CoV-2. We measured complete primary course overall VE by vaccine brand and by time since vaccination. Results: Overall VE was 74% (95% CI: 69-79), 76% (95% CI: 71-80), 63% (95% CI: 48-75) and 63% (95% CI: 16-83) among those aged 30-44, 45-59, 60-74 and ≥ 75 years, respectively. VE among those aged 30-59 years was 78% (95% CI: 75-81), 66% (95% CI: 58-73), 91% (95% CI: 87-94) and 52% (95% CI: 40-61), for Comirnaty, Vaxzevria, Spikevax and COVID-19 Vaccine Janssen, respectively. VE among people 60 years and older was 67% (95% CI: 52-77), 65% (95% CI: 48-76) and 83% (95% CI: 64-92) for Comirnaty, Vaxzevria and Spikevax, respectively. Comirnaty VE among those aged 30-59 years was 87% (95% CI: 83-89) at 14-29 days and 65% (95% CI: 56-71%) at ≥ 90 days between vaccination and onset of symptoms. Conclusions: VE against symptomatic infection with the SARS-CoV-2 Delta variant varied among brands, ranging from 52% to 91%. While some waning of the vaccine effect may be present (sample size limited this analysis to only Comirnaty), protection was 65% at 90 days or more between vaccination and onset.
Palabras clave
COVID-19 | Delta variant | Europe | SARS-CoV-2 | Multicentre study | Test-negative design | Vaccine effectiveness
MESH
COVID-19 | Influenza Vaccines | Influenza, Human | COVID-19 Vaccines | Europe | Humans | Primary Health Care | SARS-CoV-2 | Vaccination
Versión en línea
DOI
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