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dc.contributor.authorJember, Tadesse Hailu
dc.contributor.authorAmor, Arancha
dc.contributor.authorNibret, Endalkachew
dc.contributor.authorMunshea, Abaineh
dc.contributor.authorFlores-Chavez, Maria 
dc.contributor.authorTa Tang, Thuy-Huong 
dc.contributor.authorSaugar, Jose Maria 
dc.contributor.authorBenito, Agustin 
dc.contributor.authorAnegagrie, Melaku
dc.identifier.citationPLoS Negl Trop Dis. 2022 Apr 28;16(4):e0010299.es_ES
dc.description.abstractBackground: Strongyloides stercoralis is a parasite that causes strongyloidiasis in humans. It is prevalent in the tropics and sub-tropics where poor sanitation is a common problem. The true prevalence of S. stercoralis in Ethiopia is underestimated due to the lack of a "Gold" standard diagnostic method. Moreover, its prevalence across altitudinal gradient in Amhara Region has not been studied. Methods: A cross-sectional study was conducted among 844 schoolchildren in Amhara Region from April to December 2019. A stool sample was collected from each study participant and processed using formol ether concentration technique (FECT), spontaneous tube sedimentation technique (STST), Baermann concentration technique (BCT), agar plate culture (APC) and real-time polymerase chain reaction (RT-PCR). Data were entered using EpiData and analyzed by SPSS version 23 statistical software. Prevalence of S. stercoralis infection was determined using a single diagnostic technique and combination of techniques. Association of clinical variables with S. stercoralis infection was assessed by logistic regression and independent variables with p<0.05 were considered statistically significant. Results: Prevalence of soil-transmitted helminths (STHs) and S. mansoni infections was 38.0% and 20.4%, respectively. Among STHs, the prevalence of hookworm infection was 32.8%. Prevalence of S. stercoralis infection was 39.0%, 28.8%, 10.9%, 10.3%, 4.0% and 2.0% by the respective, combinations of the five methods, RT-PCR, APC, BCT, STST and FECT. The highest prevalence rates, 48.2%, 45.0% and 41.1% of S. stercoralis were recorded in the age group of 12-14 years, males and rural dwellers, respectively. Prevalence rates of S. stercoralis infection in highland, semi-highland and lowland areas were 40.4%, 41.8% and 25.9%, respectively. Having abdominal pain (AOR = 2.48; 95% CI:1.65-3.72), cough (AOR = 1.63;95%CI:1.09-2.42), urticaria (AOR = 2.49;95%CI:1.50-4.01) and being malnourished (AOR = 1.44;95%:1.10-2.01) were significantly associated with strongyloidiasis. Conclusion: Prevalence of S. stercoralis infection was high and varied across different altitudes in Amhara Region. Some clinical syndromes were found to be significantly associated with S. stercoralis infection. Therefore, proper diagnosis and preventive strategies against S. stercoralis infection are highly recommended to be devised and implemented in Amhara Region.es_ES
dc.description.sponsorshipThis study was funded by the Bahir Dar University (, Mundo Sano Foundation ( and the National Center of Tropical Medicine, from the Institute of Health Carlos III (, which supported the implementation by providing material support. We received materials and reagents but not a specific budget from funders to this project. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.publisherPublic Library of Science (PLOS) es_ES
dc.subject.meshStrongyloides stercoralis es_ES
dc.subject.meshStrongyloidiasis es_ES
dc.subject.meshAdolescent es_ES
dc.subject.meshAltitude es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshChild es_ES
dc.subject.meshCross-Sectional Studies es_ES
dc.subject.meshEthiopia es_ES
dc.subject.meshFeces es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshPrevalence es_ES
dc.titlePrevalence of Strongyloides stercoralis infection and associated clinical symptoms among schoolchildren living in different altitudes of Amhara National Regional State, northwest Ethiopiaes_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.contributor.funderBahir Dar University (Etiopía) es_ES
dc.contributor.funderFundación Mundo Sano es_ES
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.identifier.journalPLoS neglected tropical diseaseses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.centroISCIII::Centro Nacional de Medicina Tropicales_ES
dc.rights.accessRightsopen accesses_ES

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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