Publication: Illness Severity in Hospitalized Influenza Patients by Virus Type and Subtype, Spain, 2010-2017
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2020-02
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Delgado-Sanz, Concepcion ISCIII 
Mazagatos, Clara ISCIII
Oliva Dominguez, Jesus Angel ISCIII
Gherasim, Alin Manuel ISCIII
Larrauri, Amparo ISCIII 
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Centers for Disease Control and Prevention (CDC)
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Abstract
We conducted a retrospective cohort study to assess the effect of influenza virus type and subtype on disease severity among hospitalized influenza patients in Spain. We analyzed the cases of 8,985 laboratory-confirmed case-patients hospitalized for severe influenza by using data from a national surveillance system for the period 2010-2017. Hospitalized patients with influenza A(H1N1)pdm09 virus were significantly younger, more frequently had class III obesity, and had a higher risk for pneumonia or acute respiratory distress syndrome than patients infected with influenza A(H3N2) or B (p<0.05). Hospitalized patients with influenza A(H1N1)pdm09 also had a higher risk for intensive care unit admission, death, or both than patients with influenza A(H3N2) or B, independent of other factors. Determining the patterns of influenza-associated severity and how they might differ by virus type and subtype can help guide planning and implementation of adequate control and preventive measures during influenza epidemics.
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Emerg Infect Dis. 2020 Feb;26(2):220-228.