Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/14873
Título
Early Cellular and Humoral Responses Developed in Oncohematological Patients after Vaccination with One Dose against COVID-19
Autor(es)
Rodríguez-Mora, Sara ISCIII | Corona, Magdalena | Torres, Montserrat ISCIII | Casado-Fernández, Guiomar ISCIII | García-Pérez, Javier ISCIII | Ramos-Martín, Fernando ISCIII | Vigon-Hernandez, Lorena ISCIII | Manzanares, Mario | Mateos, Elena ISCIII | Martín-Moro, Fernando | Zurdo-Castronuño, Alejandro | Murciano-Antón, María Aranzazu | Alcamí, José ISCIII | Perez-Olmeda, Mayte ISCIII | López-Jiménez, Javier | García-Gutiérrez, Valentín | Coiras, Mayte ISCIII | Multidisciplinary Group of Study of COVID-19 (MGS-COVID)
Fecha de publicación
2022-05-16
Cita
J Clin Med. 2022 May 16;11(10):2803.
Idioma
Inglés
Tipo de documento
research article
Resumen
Individuals with oncohematological diseases (OHD) may develop an impaired immune response against vaccines due to the characteristics of the disease or to its treatment. Humoral response against SARS-CoV-2 has been described to be suboptimal in these patients, but the quality and efficiency of the cellular immune response has not been yet completely characterized. In this study, we analyzed the early humoral and cellular immune responses in individuals with different OHD after receiving one dose of an authorized vaccine against SARS-CoV-2. Humoral response, determined by antibodies titers and neutralizing capacity, was overall impaired in individuals with OHD, except for the cohort of chronic myeloid leukemia (CML), which showed higher levels of specific IgGs than healthy donors. Conversely, the specific direct cytotoxic cellular immunity response (DCC) against SARS-CoV-2, appeared to be enhanced, especially in individuals with CML and chronic lymphocytic leukemia (CLL). This increased cellular immune response, developed earlier than in healthy donors, showed a modest cytotoxic activity that was compensated by significantly increased numbers, likely due to the disease or its treatment. The analysis of the immune response through subsequent vaccine doses will help establish the real efficacy of COVID-19 vaccines in individuals with OHD.
Palabras clave
COVID-19 vaccine | Cytotoxic response | Early immune | Hematological malignancies | Humoral response
Versión en línea
DOI
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