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dc.contributor.author | Agud, Martin | |
dc.contributor.author | Medrano, Inés de | |
dc.contributor.author | Mendez-Echevarria, Ana | |
dc.contributor.author | Sainz, Talia | |
dc.contributor.author | Roman, Federico | |
dc.contributor.author | Ruiz Carrascoso, Guillermo | |
dc.contributor.author | Escosa-Garcia, Luis | |
dc.contributor.author | Molina Amores, Clara | |
dc.contributor.author | Climent, Francisco José | |
dc.contributor.author | Rodríguez, Aroa | |
dc.contributor.author | Garcia-Fernandez de Villalta, Marta | |
dc.contributor.author | Calvo, Cristina | |
dc.date.accessioned | 2022-08-05T07:29:15Z | |
dc.date.available | 2022-08-05T07:29:15Z | |
dc.date.issued | 2022-05-04 | |
dc.identifier.citation | Sci Rep. 2022 May 4;12(1):7223. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/14856 | |
dc.description.abstract | To assess drug-resistant bacterial colonisation rates and associated risk factors in children with complex chronic conditions admitted to a national reference unit in Spain. Cross-sectional study that included all children admitted to our unit from September 2018 to July 2019. Rectal swabs were obtained to determine multidrug-resistant Gram-negative bacilli (MR-GNB) colonisation, and nasal swab to determine S. aureus and methicillin-resistant S. aureus (MRSA) colonisation. Medical records were reviewed. 100 children were included, with a median of four complex chronic conditions. Sixteen percent had S. aureus colonisation, including two MRSA. S. aureus colonisation was associated with technology-dependent children, while being on antibiotic prophylaxis or having undergone antibiotic therapy in the previous month were protective factors. The prevalence of MR-GNB colonisation was 27%, which was associated with immunosuppressive therapy (aOR 31; 2.02-47]; p = 0.01), antibiotic prophylaxis (aOR 4.56; 1.4-14.86; p = 0.012), previously treated skin-infections (aOR 2.9; 1.07-8.14; p = 0.03), surgery in the previous year (aOR 1.4; 1.06-1.8; p = 0.014), and hospital admission in the previous year (aOR 1.79; [1.26-2.56]; p = 0.001). The rate of S. aureus nasal colonisation in this series was not high despite the presence of chronic conditions, and few cases corresponded to MRSA. Antibiotic prophylaxis, immunosuppressive therapies, history of infections, previous surgeries, and length of admission in the previous year were risk factors for MR-GNB colonisation. | es_ES |
dc.description.sponsorship | This study was supported by The Spanish Ministry of Science and Innovation –Carlos III Health Institute, and European Regional Development Funds; Grant No. PI18CIII/00372 [Fondo de Investigaciones Sanitarias-Spanish Health Research Fund (ISCIII)]; Grant Award “Jose María Corretger” from the Spanish Society for Paediatric Infectious Diseases; Grant Research Award from the Spanish Association of Paediatric Primary Care; and a small grant award from the European Society for Paediatric Infectious Diseases. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Methicillin-Resistant Staphylococcus aureus | es_ES |
dc.subject.mesh | Staphylococcal Infections | es_ES |
dc.subject.mesh | Anti-Bacterial Agents | es_ES |
dc.subject.mesh | Carrier State | es_ES |
dc.subject.mesh | Child | es_ES |
dc.subject.mesh | Chronic Disease | es_ES |
dc.subject.mesh | Cross-Sectional Studies | es_ES |
dc.subject.mesh | Gram-Negative Bacteria | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Prevalence | es_ES |
dc.subject.mesh | Risk Factors | es_ES |
dc.subject.mesh | Staphylococcus aureus | es_ES |
dc.title | Risk factors for antibiotic-resistant bacteria colonisation in children with chronic complex conditions | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 35508685 | es_ES |
dc.format.volume | 12 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 7223 | es_ES |
dc.identifier.doi | 10.1038/s41598-022-11295-5 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | European Regional Development Fund | es_ES |
dc.contributor.funder | European Society for Paediatric Infectious Diseases | es_ES |
dc.contributor.funder | Sociedad Española de Enfermedades Infecciosas Pediátricas | es_ES |
dc.contributor.funder | Asociación Española de Atención Primaria de Pediatría | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2045-2322 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/s41598-022-11295-5 | es_ES |
dc.identifier.journal | Scientific Reports | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI18CIII/00372 | es_ES |