dc.contributor.author | van Wamelen, Daniel J | |
dc.contributor.author | Sauerbier, Anna | |
dc.contributor.author | Leta, Valentina | |
dc.contributor.author | Rodriguez-Blazquez, Carmen | |
dc.contributor.author | Falup-Pecurariu, Cristian | |
dc.contributor.author | Rodriguez-Violante, Mayela | |
dc.contributor.author | Rizos, Alexandra | |
dc.contributor.author | Tsuboi, Y | |
dc.contributor.author | Metta, Vinod | |
dc.contributor.author | Bhidayasiri, Roongroj | |
dc.contributor.author | Bhattacharya, Kalyan | |
dc.contributor.author | Borgohain, Rupam | |
dc.contributor.author | Prashanth, L K | |
dc.contributor.author | Rosales, Raymond | |
dc.contributor.author | Lewis, Simon | |
dc.contributor.author | Fung, Victor | |
dc.contributor.author | Behari, Madhuri | |
dc.contributor.author | Goyal, Vinay | |
dc.contributor.author | Kishore, Asha | |
dc.contributor.author | Lloret, Santiago Perez | |
dc.contributor.author | Martínez-Martín, Pablo | |
dc.contributor.author | Chaudhuri, K Ray | |
dc.date.accessioned | 2022-07-20T08:21:31Z | |
dc.date.available | 2022-07-20T08:21:31Z | |
dc.date.issued | 2021-05-05 | |
dc.identifier.citation | Sci Rep. 2021 May 5;11(1):9611. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/14733 | |
dc.description.abstract | Growing evidence suggests that non-motor symptoms (NMS) in Parkinson's disease (PD) have differential progression patterns that have a different natural history from motor progression and may be geographically influenced. We conducted a cross-sectional analysis of 1607 PD patients of whom 1327 were from Europe, 208 from the Americas, and 72 from Asia. The primary objective was to assess baseline non-motor burden, defined by Non-Motor Symptoms Scale (NMSS) total scores. Other aims included identifying the factors predicting quality of life, differences in non-motor burden between drug-naïve and non-drug-naïve treated patients, and non-motor phenotypes across different geographical locations. Mean age was 65.9 ± 10.8 years, mean disease duration 6.3 ± 5.6 years, median Hoehn and Yahr stage was 2 (2-3), and 64.2% were male. In this cohort, mean NMSS scores were 46.7 ± 37.2. Differences in non-motor burden and patterns differed significantly between drug-naïve participants, those with a disease duration of less than five years, and those with a duration of five years or over (p ≤ 0.018). Significant differences were observed in geographical distribution (NMSS Europe: 46.4 ± 36.3; Americas: 55.3 ± 42.8; Asia: 26.6 ± 25.1; p < 0.001), with differences in sleep/fatigue, urinary, sexual, and miscellaneous domains (p ≤ 0.020). The best predictor of quality of life was the mood/apathy domain (β = 0.308, p < 0.001). This global study reveals that while non-motor symptoms are globally present with severe NMS burden impacting quality of life in PD, there appear to be differences depending on disease duration and geographical distribution. | es_ES |
dc.description.sponsorship | This article presents independent research funded by the National Institute for Health Research (NIHR) Mental Health Biomedical Research Centre and Dementia Unit at South London and Maudsley NHS Foundation Trust and King’s College London. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Quality of Life | es_ES |
dc.subject.mesh | Aged | es_ES |
dc.subject.mesh | Apathy | es_ES |
dc.subject.mesh | Cross-Sectional Studies | es_ES |
dc.subject.mesh | Fatigue | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Longitudinal Studies | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Parkinson Disease | es_ES |
dc.subject.mesh | Severity of Illness Index | es_ES |
dc.subject.mesh | Sleep | es_ES |
dc.subject.mesh | Surveys and Questionnaires | es_ES |
dc.title | Cross-sectional analysis of the Parkinson's disease Non-motor International Longitudinal Study baseline non-motor characteristics, geographical distribution and impact on quality of life | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 33953218 | es_ES |
dc.format.volume | 11 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 9611 | es_ES |
dc.identifier.doi | 10.1038/s41598-021-88651-4 | es_ES |
dc.contributor.funder | NIHR - Mental Health Biomedical Research Centre (Reino Unido) | es_ES |
dc.contributor.funder | Imperial College London (Reino Unido) | es_ES |
dc.contributor.funder | South London and Maudsley NHS Foundation Trust (Reino Unido) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2045-2322 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/s41598-021-88651-4 | es_ES |
dc.identifier.journal | Scientific Reports | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |