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dc.contributor.authorGámbaro, Fabiana
dc.contributor.authorPérez, Ana Belén
dc.contributor.authorAgüera, Eduardo
dc.contributor.authorProt, Matthieu
dc.contributor.authorMartínez-Martínez, Luis
dc.contributor.authorCabrerizo, Maria 
dc.contributor.authorSimon-Loriere, Etienne
dc.contributor.authorFernandez-Garcia, Maria Dolores 
dc.date.accessioned2022-05-25T12:33:37Z
dc.date.available2022-05-25T12:33:37Z
dc.date.issued2021-11-02
dc.identifier.citationSci Rep. 2021 Nov 2;11(1):21523.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/14531
dc.descriptionAuthor Correction: Genomic surveillance of enterovirus associated with aseptic meningitis cases in southern Spain, 2015-2018. Sci Rep. 2021 Nov 18;11(1):22899. doi: 10.1038/s41598-021-02194-2.es_ES
dc.description.abstractNew circulating Enterovirus (EV) strains often emerge through recombination. Upsurges of recombinant non-polio enteroviruses (NPEVs) associated with neurologic manifestations such as EVA71 or Echovirus 30 (E30) are a growing public health concern in Europe. Only a few complete genomes of EVs circulating in Spain are available in public databases, making it difficult to address the emergence of recombinant EVs, understand their evolutionary relatedness and the possible implication in human disease. We have used metagenomic (untargeted) NGS to generate full-length EV genomes from CSF samples of EV-positive aseptic meningitis cases in Southern Spain between 2015 and 2018. Our analyses reveal the co-circulation of multiple Enterovirus B (EV-B) types (E6, E11, E13 and E30), including a novel E13 recombinant form. We observed a genetic turnover where emergent lineages (C1 for E6 and I [tentatively proposed in this study] for E30) replaced previous lineages circulating in Spain, some concomitant with outbreaks in other parts of Europe. Metagenomic sequencing provides an effective approach for the analysis of EV genomes directly from PCR-positive CSF samples. The detection of a novel, disease-associated, recombinant form emphasizes the importance of genomic surveillance to monitor spread and evolution of EVs.es_ES
dc.description.sponsorshipThis work was funded by the Junta de Andalucía, Consejería de Salud y Familias (Project number PI-0216-2019) and by the Acción Estratégica en Salud Intramural (Project number PI20CIII/00005). MD Fernandez-Garcia received a Miguel Servet Research Contract (CP18/00067) from the Strategic Action in Health 2018 and funded by National Institute of Health Carlos III (ISCIII). ESL acknowledges funding from the INCEPTION programme (Investissements d’Avenir grant ANR-16-CONV-0005).es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Group es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.titleGenomic surveillance of enterovirus associated with aseptic meningitis cases in southern Spain, 2015-2018es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.rights.licenseAtribución-NoComercial 4.0 Internacional*
dc.identifier.pubmedID34728763es_ES
dc.format.volume11es_ES
dc.format.number1es_ES
dc.format.page21523es_ES
dc.identifier.doi10.1038/s41598-021-01053-4es_ES
dc.contributor.funderRegional Government of Andalusia (España) es_ES
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.contributor.funderNvidia Corporationes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2045-2322es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-021-01053-4es_ES
dc.identifier.journalScientific Reportses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.relation.projectFISinfo:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/null/Contratos Miguel Servet (2018)/CP18/00067es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/PI20CIII/00005es_ES


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