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dc.contributor.author | Gámbaro, Fabiana | |
dc.contributor.author | Pérez, Ana Belén | |
dc.contributor.author | Agüera, Eduardo | |
dc.contributor.author | Prot, Matthieu | |
dc.contributor.author | Martínez-Martínez, Luis | |
dc.contributor.author | Cabrerizo, Maria | |
dc.contributor.author | Simon-Loriere, Etienne | |
dc.contributor.author | Fernandez-Garcia, Maria Dolores | |
dc.date.accessioned | 2022-05-25T12:33:37Z | |
dc.date.available | 2022-05-25T12:33:37Z | |
dc.date.issued | 2021-11-02 | |
dc.identifier.citation | Sci Rep. 2021 Nov 2;11(1):21523. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/14531 | |
dc.description | Author Correction: Genomic surveillance of enterovirus associated with aseptic meningitis cases in southern Spain, 2015-2018. Sci Rep. 2021 Nov 18;11(1):22899. doi: 10.1038/s41598-021-02194-2. | es_ES |
dc.description.abstract | New circulating Enterovirus (EV) strains often emerge through recombination. Upsurges of recombinant non-polio enteroviruses (NPEVs) associated with neurologic manifestations such as EVA71 or Echovirus 30 (E30) are a growing public health concern in Europe. Only a few complete genomes of EVs circulating in Spain are available in public databases, making it difficult to address the emergence of recombinant EVs, understand their evolutionary relatedness and the possible implication in human disease. We have used metagenomic (untargeted) NGS to generate full-length EV genomes from CSF samples of EV-positive aseptic meningitis cases in Southern Spain between 2015 and 2018. Our analyses reveal the co-circulation of multiple Enterovirus B (EV-B) types (E6, E11, E13 and E30), including a novel E13 recombinant form. We observed a genetic turnover where emergent lineages (C1 for E6 and I [tentatively proposed in this study] for E30) replaced previous lineages circulating in Spain, some concomitant with outbreaks in other parts of Europe. Metagenomic sequencing provides an effective approach for the analysis of EV genomes directly from PCR-positive CSF samples. The detection of a novel, disease-associated, recombinant form emphasizes the importance of genomic surveillance to monitor spread and evolution of EVs. | es_ES |
dc.description.sponsorship | This work was funded by the Junta de Andalucía, Consejería de Salud y Familias (Project number PI-0216-2019) and by the Acción Estratégica en Salud Intramural (Project number PI20CIII/00005). MD Fernandez-Garcia received a Miguel Servet Research Contract (CP18/00067) from the Strategic Action in Health 2018 and funded by National Institute of Health Carlos III (ISCIII). ESL acknowledges funding from the INCEPTION programme (Investissements d’Avenir grant ANR-16-CONV-0005). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.title | Genomic surveillance of enterovirus associated with aseptic meningitis cases in southern Spain, 2015-2018 | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.rights.license | Atribución-NoComercial 4.0 Internacional | * |
dc.identifier.pubmedID | 34728763 | es_ES |
dc.format.volume | 11 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 21523 | es_ES |
dc.identifier.doi | 10.1038/s41598-021-01053-4 | es_ES |
dc.contributor.funder | Regional Government of Andalusia (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Nvidia Corporation | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2045-2322 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/s41598-021-01053-4 | es_ES |
dc.identifier.journal | Scientific Reports | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/null/Contratos Miguel Servet (2018)/CP18/00067 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI20CIII/00005 | es_ES |