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dc.contributor.author | Garcia-Vidal, Carolina | |
dc.contributor.author | Iglesias-Caballero, Maria | |
dc.contributor.author | Puerta-Alcalde, Pedro | |
dc.contributor.author | Mas-Lloret, Vicente | |
dc.contributor.author | Cuesta-Chasco, Genoveva | |
dc.contributor.author | Garcia-Pouton, Nicole | |
dc.contributor.author | Varona Fernandez, Sarai | |
dc.contributor.author | Pozo Sanchez, Francisco | |
dc.contributor.author | Vazquez-Moron, Sonia | |
dc.contributor.author | Marcos, Maria Angeles | |
dc.contributor.author | Soriano, Alex | |
dc.contributor.author | Casas Flecha, Inmaculada | |
dc.contributor.author | HEMATOCOVID19-Researchers Group | |
dc.date.accessioned | 2022-05-24T08:25:52Z | |
dc.date.available | 2022-05-24T08:25:52Z | |
dc.date.issued | 2022-03-03 | |
dc.identifier.citation | Front Microbiol. 2022 Mar 3;13:826883. | es_ES |
dc.identifier.issn | 1664-302X | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/14475 | |
dc.description.abstract | We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of viral mutations was documented after the consecutive use of antivirals and convalescent plasma. The virus detected in the last of 12 clinical samples (day 237) had accumulated 22 changes in amino acids and 29 in nucleotides. Some of these changes, such as the E484Q, were mutations of concern as defined by WHO. This finding represents an enormous epidemiological threat and poses a major clinical challenge. Combined antiviral strategies, as well as specific strategies related to the diagnostic approach of prolonged infections for this specific population, may be needed. | es_ES |
dc.description.sponsorship | This work has been financed by funds for research ad hoc COVID-19 from patronage provided by citizens and organizations to Hospital Clínic de Barcelona-Fundació Clínic per a la Recerca Biomèdica. This work received support from FONDO-COVID19 (ISCIII Grant number: COV20-00679), Instituto de Salud Carlos III (PI21/01640) and by European Region (ERDF, “A way to make Europe”). PP-A [JR20/00012 and PI21/00498], NG-P [FI19/00133], have also received research grants from the Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III. The funders had neither a specific role in study design or collection of data, nor in writing of the paper or decision to submit. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | COVID-19 | es_ES |
dc.subject | Antivirals | es_ES |
dc.subject | Hematology | es_ES |
dc.subject | Immunosuppression | es_ES |
dc.subject | Mutations | es_ES |
dc.subject | Persistence | es_ES |
dc.subject | Remdesivir | es_ES |
dc.title | Emergence of Progressive Mutations in SARS-CoV-2 From a Hematologic Patient With Prolonged Viral Replication | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 35308337 | es_ES |
dc.format.volume | 13 | es_ES |
dc.format.page | 826883 | es_ES |
dc.identifier.doi | 10.3389/fmicb.2022.826883 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Hospital Clínic de Barcelona | es_ES |
dc.contributor.funder | Ministerio de Sanidad (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.3389/fmicb.2022.826883 | es_ES |
dc.identifier.journal | Frontiers in Microbiology | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/COV20-00679 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/JR20/00012 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI21/00498 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/FI19/00133 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/PI21/01640 | es_ES |