Show simple item record

dc.contributor.authorMancebo, Francisco José 
dc.contributor.authorParras-Moltó, Marcos
dc.contributor.authorGarcía-Ríos, Estéfani 
dc.contributor.authorPerez-Romero, Pilar 
dc.date.accessioned2022-05-23T14:44:11Z
dc.date.available2022-05-23T14:44:11Z
dc.date.issued2022-03-02
dc.identifier.citationInt J Mol Sci. 2022 Mar 2;23(5):2768.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/14466
dc.description.abstractCMV is a major cause of morbidity and mortality in immunocompromised individuals that will benefit from the availability of a vaccine. Despite the efforts made during the last decade, no CMV vaccine is available. An ideal CMV vaccine should elicit a broad immune response against multiple viral antigens including proteins involved in virus-cell interaction and entry. However, the therapeutic use of neutralizing antibodies targeting glycoproteins involved in viral entry achieved only partial protection against infection. In this scenario, a better understanding of the CMV proteome potentially involved in viral entry may provide novel candidates to include in new potential vaccine design. In this study, we aimed to explore the CMV genome to identify proteins with putative transmembrane domains to identify new potential viral envelope proteins. We have performed in silico analysis using the genome sequences of nine different CMV strains to predict the transmembrane domains of the encoded proteins. We have identified 77 proteins with transmembrane domains, 39 of which were present in all the strains and were highly conserved. Among the core proteins, 17 of them such as UL10, UL139 or US33A have no ascribed function and may be good candidates for further mechanistic studies.es_ES
dc.description.sponsorshipThis study was supported by the Spanish Ministry of Science, Innovation and University, Instituto de Salud Carlos III Grant/Award Numbers: PI17CIII-00014 (MPY110/18); DTS18CIII/00006 (MPY127/19); PI20-009 (MPY303/20). E.G-R is supported by the Sara Borrell Program (CD18CIII/00007), Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades. FJ.M is supported by the PFIS Program (F18III/00013), Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades.MP-M is supported by the Swedish Research Council (VR) (2019–03482).es_ES
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCytomegaloviruses_ES
dc.subjectPangenomees_ES
dc.subjectProteomees_ES
dc.subjectTransmembrane.es_ES
dc.titleDeciphering the Potential Coding of Human Cytomegalovirus: New Predicted Transmembrane Proteomees_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID35269907es_ES
dc.format.volume23es_ES
dc.format.number5es_ES
dc.format.page2768es_ES
dc.identifier.doi10.3390/ijms23052768es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.contributor.funderSwedish Research Counciles_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1422-0067es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/ijms23052768es_ES
dc.identifier.journalInternational Journal of Molecular Scienceses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/PI17CIII-00014es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/DTS18CIII/00006es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/PI20-009es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/CD18CIII/00007es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/F18III/00013es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/MPY110/18es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/MPY127/19es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/MPY303/20es_ES


Files in this item

Acceso Abierto
Thumbnail
Acceso Abierto
Acceso Abierto
Thumbnail
Acceso Abierto
Thumbnail
Acceso Abierto
Thumbnail
Acceso Abierto
Thumbnail
Acceso Abierto
Thumbnail
Acceso Abierto
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Atribución 4.0 Internacional
This item is licensed under a: Atribución 4.0 Internacional