Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/14350
Título
Predicted Epitope Abundance Supports Vaccine-Induced Cytotoxic Protection Against SARS-CoV-2 Variants of Concern
Autor(es)
Martin-Galiano, Antonio Javier ISCIII | Díez-Fuertes, Francisco ISCIII | McConnell, Michael J ISCIII | Lopez, Daniel ISCIII
Fecha de publicación
2021-11
Cita
Front Immunol. 2021 Nov 25;12:732693.
Idioma
Inglés
Tipo de documento
journal article
Resumen
The effect of emerging SARS-CoV-2 variants on vaccine efficacy is of critical importance. In this study, the potential impact of mutations that facilitate escape from the cytotoxic cellular immune response in these new virus variants for the 551 most abundant HLA class I alleles was analyzed. Computational prediction showed that most of these alleles, that cover >90% of the population, contain enough epitopes without escape mutations in the principal SARS-CoV-2 variants. These data suggest that the cytotoxic cellular immune protection elicited by vaccination is not greatly affected by emerging SARS-CoV-2 variants.
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