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dc.contributor.authorSchwarz, Christine
dc.contributor.authorPedraza-Flechas, Ana María
dc.contributor.authorPastor-Barriuso, Roberto 
dc.contributor.authorLope, Virginia 
dc.contributor.authorFernandez de Larrea, Nerea 
dc.contributor.authorJimenez-Moleon, Jose J.
dc.contributor.authorPollan-Santamaria, Marina 
dc.contributor.authorPerez-Gomez, Beatriz 
dc.date.accessioned2022-05-09T11:11:04Z
dc.date.available2022-05-09T11:11:04Z
dc.date.issued2021-11
dc.identifier.citationCancers (Basel). 2021 Nov 26;13(23):5952.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/14335
dc.description.abstractThis systematic review discusses long-term NSW and female BC risk, with special attention to differences between pre- and postmenopausal BC, to test the association with recent NSW. The review follows PRISMA guidelines (Prospero registry: CRD42018102515). We searched PubMed, Embase, and WOS for case-control, nested case-control, and cohort studies addressing long-term NSW (≥15 years) as risk exposure and female BC as outcome until 31 December 2020. Risk of bias was evaluated with the Newcastle-Ottawa scale. Eighteen studies were finally included (eight cohorts; five nested case-control; five case-control). We performed meta-analyses on long-term NSW and BC risk; overall and by menopausal status; a subanalysis on recent long-term NSW, based on studies involving predominantly women below retirement age; and a dose-response meta-analysis on NSW duration. The pooled estimate for long-term NSW and BC was 1.13 (95%CI = 1.01-1.27; 18 studies, I2 = 56.8%, p = 0.002). BC risk increased 4.7% per 10 years of NSW (95%CI = 0.94-1.09; 16 studies, I2 = 33.4%, p = 0.008). The pooled estimate for premenopausal BC was 1.27 (95%CI = 0.96-1.68; six studies, I2 = 32.0%, p = 0.196) and for postmenopausal BC 1.05 (95%CI = 0.90-1.24,I2 = 52.4%; seven studies, p = 0.050). For recent long-term exposure, the pooled estimate was 1.23 (95%CI = 1.06-1.42; 15 studies; I2 = 48.4%, p = 0.018). Our results indicate that long-term NSW increases the risk for BC and that menopausal status and time since exposure might be relevant.es_ES
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectBreast canceres_ES
dc.subjectMenopausal statuses_ES
dc.subjectMeta-analysises_ES
dc.subjectNightshift workes_ES
dc.subjectOccupational exposurees_ES
dc.subjectRecent exposurees_ES
dc.subjectRetirement agees_ES
dc.titleLong-Term Nightshift Work and Breast Cancer Risk: An Updated Systematic Review and Meta-Analysis with Special Attention to Menopausal Status and to Recent Nightshift Workes_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID34885062es_ES
dc.format.volume13es_ES
dc.format.number23es_ES
dc.format.page5952es_ES
dc.identifier.doi10.3390/cancers13235952es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2072-6694es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/cancers13235952es_ES
dc.identifier.journalCancerses_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES
dc.repisalud.centroISCIII::Escuela Nacional de Sanidades_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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