Mostrar el registro sencillo del ítem

dc.contributor.authorSchlosser, Pascal
dc.contributor.authorTin, Adrienne
dc.contributor.authorMatias-Garcia, Pamela R.
dc.contributor.authorThio, Chris H. L.
dc.contributor.authorJoehanes, Roby
dc.contributor.authorLiu, Hongbo
dc.contributor.authorWeihs, Antoine
dc.contributor.authorYu, Zhi
dc.contributor.authorHoppmann, Anselm
dc.contributor.authorGrundner-Culemann, Franziska
dc.contributor.authorMin, Josine L.
dc.contributor.authorAdeyemo, Adebowale A.
dc.contributor.authorAgyemang, Charles
dc.contributor.authorÄrnlöv, Johan
dc.contributor.authorAziz, Nasir A.
dc.contributor.authorBaccarelli, Andrea
dc.contributor.authorBochud, Murielle
dc.contributor.authorBrenner, Hermann
dc.contributor.authorBreteler, Monique M. B.
dc.contributor.authorCarmeli, Cristian
dc.contributor.authorChaker, Layal
dc.contributor.authorChambers, John C.
dc.contributor.authorCole, Shelley A.
dc.contributor.authorCoresh, Josef
dc.contributor.authorCorre, Tanguy
dc.contributor.authorCorrea, Adolfo
dc.contributor.authorCox, Simon R.
dc.contributor.authorde Klein, Niek
dc.contributor.authorDelgado, Graciela E.
dc.contributor.authorDomingo-Relloso, Arce 
dc.contributor.authorEckardt, Kai-Uwe
dc.contributor.authorEkici, Arif B.
dc.contributor.authorEndlich, Karlhans
dc.contributor.authorEvans, Kathryn L.
dc.contributor.authorFloyd, James S.
dc.contributor.authorFornage, Myriam
dc.contributor.authorFranke, Lude
dc.contributor.authorFraszczyk, Eliza
dc.contributor.authorGao, Xu
dc.contributor.authorGào, Xīn
dc.contributor.authorGhanbari, Mohsen
dc.contributor.authorGhasemi, Sahar
dc.contributor.authorGieger, Christian
dc.contributor.authorGreenland, Philip
dc.contributor.authorGrove, Megan L.
dc.contributor.authorHarris, Sarah E.
dc.contributor.authorHemani, Gibran
dc.contributor.authorHenneman, Peter
dc.contributor.authorHerder, Christian
dc.contributor.authorHorvath, Steve
dc.contributor.authorHou, Lifang
dc.contributor.authorHurme, Mikko A.
dc.contributor.authorHwang, Shih-Jen
dc.contributor.authorJarvelin, Marjo-Riitta
dc.contributor.authorKardia, Sharon L. R.
dc.contributor.authorKasela, Silva
dc.contributor.authorKleber, Marcus E.
dc.contributor.authorKoenig, Wolfgang
dc.contributor.authorKooner, Jaspal S.
dc.contributor.authorKramer, Holly
dc.contributor.authorKronenberg, Florian
dc.contributor.authorKühnel, Brigitte
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorLind, Lars
dc.contributor.authorLiu, Dan
dc.contributor.authorLiu, Yongmei
dc.contributor.authorLloyd-Jones, Donald M.
dc.contributor.authorLohman, Kurt
dc.contributor.authorLorkowski, Stefan
dc.contributor.authorLu, Ake T.
dc.contributor.authorMarioni, Riccardo E.
dc.contributor.authorMärz, Winfried
dc.contributor.authorMcCartney, Daniel L.
dc.contributor.authorMeeks, Karlijn A. C.
dc.contributor.authorMilani, Lili
dc.contributor.authorMishra, Pashupati P.
dc.contributor.authorNauck, Matthias
dc.contributor.authorNavas-Acien, Ana 
dc.contributor.authorNowak, Christoph
dc.contributor.authorPeters, Annette
dc.contributor.authorProkisch, Holger
dc.contributor.authorPsaty, Bruce M.
dc.contributor.authorRaitakari, Olli T.
dc.contributor.authorRatliff, Scott M.
dc.contributor.authorReiner, Alex P.
dc.contributor.authorRosas, Sylvia E.
dc.contributor.authorSchöttker, Ben
dc.contributor.authorSchwartz, Joel
dc.contributor.authorSedaghat, Sanaz
dc.contributor.authorSmith, Jennifer A.
dc.contributor.authorSotoodehnia, Nona
dc.contributor.authorStocker, Hannah R.
dc.contributor.authorStringhini, Silvia
dc.contributor.authorSundström, Johan
dc.contributor.authorSwenson, Brenton R.
dc.contributor.authorTellez-Plaza, Maria 
dc.contributor.authorvan Meurs, Joyce B. J.
dc.contributor.authorvan Vliet-Ostaptchouk, Jana V.
dc.contributor.authorVenema, Andrea
dc.contributor.authorVerweij, Niek
dc.contributor.authorWalker, Rosie M.
dc.contributor.authorWielscher, Matthias
dc.contributor.authorWinkelmann, Juliane
dc.contributor.authorWolffenbuttel, Bruce H. R.
dc.contributor.authorZhao, Wei
dc.contributor.authorZheng, Yinan
dc.contributor.authorLoh, Marie
dc.contributor.authorSnieder, Harold
dc.contributor.authorLevy, Daniel
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorSusztak, Katalin
dc.contributor.authorKöttgen, Anna
dc.contributor.authorTeumer, Alexander
dc.contributor.authorEstonian Biobank Research Team
dc.contributor.authorGenetics of DNA Methylation Consortium
dc.date.accessioned2022-05-09T10:59:12Z
dc.date.available2022-05-09T10:59:12Z
dc.date.issued2021-12
dc.identifier.citationNat Commun. 2021 Dec 9;12(1):7174.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/14334
dc.description.abstractChronic kidney disease is a major public health burden. Elevated urinary albumin-to-creatinine ratio is a measure of kidney damage, and used to diagnose and stage chronic kidney disease. To extend the knowledge on regulatory mechanisms related to kidney function and disease, we conducted a blood-based epigenome-wide association study for estimated glomerular filtration rate (n = 33,605) and urinary albumin-to-creatinine ratio (n = 15,068) and detected 69 and seven CpG sites where DNA methylation was associated with the respective trait. The majority of these findings showed directionally consistent associations with the respective clinical outcomes chronic kidney disease and moderately increased albuminuria. Associations of DNA methylation with kidney function, such as CpGs at JAZF1, PELI1 and CHD2 were validated in kidney tissue. Methylation at PHRF1, LDB2, CSRNP1 and IRF5 indicated causal effects on kidney function. Enrichment analyses revealed pathways related to hemostasis and blood cell migration for estimated glomerular filtration rate, and immune cell activation and response for urinary albumin-to-creatinineratio-associated CpGs.es_ES
dc.description.sponsorshipOpen Access funding enabled and organized by Projekt DEAL.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Group es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectChronic kidney diseasees_ES
dc.subjectDNA methylationes_ES
dc.subjectEpidemiologyes_ES
dc.subjectTranslational researches_ES
dc.titleMeta-analyses identify DNA methylation associated with kidney function and damagees_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID34887417es_ES
dc.format.volume12es_ES
dc.format.number1es_ES
dc.format.page7174es_ES
dc.identifier.doi10.1038/s41467-021-27234-3es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2041-1723es_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41467-021-27234-3es_ES
dc.identifier.journalNature Communicationses_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES


Ficheros en el ítem

Acceso Abierto
Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional