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dc.contributor.authorCeballos, Francisco C 
dc.contributor.authorRyan, Pablo
dc.contributor.authorBlancas, Rafael
dc.contributor.authorMartin-Vicente, Maria 
dc.contributor.authorVidal-Alcántara, Erick Joan 
dc.contributor.authorPeréz-García, Felipe
dc.contributor.authorBartolomé-Sánchez, Sofía 
dc.contributor.authorChurruca-Sarasqueta, Juan
dc.contributor.authorVirseda-Berdices, Ana 
dc.contributor.authorMartínez-González, Oscar
dc.contributor.authorBrochado-Kith, Oscar 
dc.contributor.authorRava, Marta 
dc.contributor.authorVilches-Medkouri, Carolina
dc.contributor.authorBlanca-López, Natalia
dc.contributor.authorRamirez Martinez-Acitores, Ignacio
dc.contributor.authorMoreira-Escriche, Patricia
dc.contributor.authorDe Juan, Carmen
dc.contributor.authorResino, Salvador 
dc.contributor.authorFernandez-Rodriguez, Amanda 
dc.contributor.authorJimenez-Sousa, Maria Angeles 
dc.date.accessioned2022-05-05T11:40:32Z
dc.date.available2022-05-05T11:40:32Z
dc.date.issued2021
dc.identifier.citationFront Med (Lausanne). 2021 Sep 30;8:718053.es_ES
dc.identifier.issn2296-858Xes_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/14275
dc.description.abstractBackground: The link between coagulation system disorders and COVID-19 has not yet been fully elucidated. Aim: Evaluating the association of non-previously reported coagulation proteins with COVID-19 severity and mortality. Design: Cross-sectional study of 134 COVID-19 patients recruited at admission and classified according to the highest COVID-19 severity reached (asymptomatic/mild, moderate, or severe) and 16 healthy control individuals. Methods: Coagulation proteins levels (antithrombin, prothrombin, factor_XI, factor_XII, and factor_XIII) and CRP were measured in plasma by the ProcartaPlex Panel (Invitrogen) multiplex immunoassay upon diagnosis. Results: We found higher levels of antithrombin, prothrombin, factor XI, factor XII, and factor XIII in asymptomatic/mild and moderate COVID-19 patients compared to healthy individuals. Interestingly, decreased levels of antithrombin and factors XI, XII, and XIII were observed in those patients who eventually developed severe illness. Additionally, survival models showed us that patients with lower levels of these coagulation proteins had an increased risk of death. Conclusion: COVID-19 provokes early increments of some specific coagulation proteins in most patients. However, lower levels of these proteins at diagnosis might "paradoxically" imply a higher risk of progression to severe disease and COVID-19-related mortality.es_ES
dc.description.sponsorshipThis study was supported by grants from Instituto de Salud Carlos III [ISCIII; Grant Number COV20/1144 (MPY224/20) to AF-R/MJ-S]. AF-R, MJ-S, and MR are Miguel Servet researchers supported and funded by ISCIII (Grant Numbers: CP14CIII/00010 to AF-R, CP17CIII/00007 to MJ-S, and CP19CIII/00002 to MR).es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Media es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCOVID-19es_ES
dc.subjectSARSes_ES
dc.subjectSARS-CoV-2es_ES
dc.subjectCoagulation factorses_ES
dc.subjectMortalityes_ES
dc.titleAre Reduced Levels of Coagulation Proteins Upon Admission Linked to COVID-19 Severity and Mortality?es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID34660629es_ES
dc.format.volume8es_ES
dc.format.page718053es_ES
dc.identifier.doi10.3389/fmed.2021.718053es_ES
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fmed.2021.718053es_ES
dc.identifier.journalFrontiers in Medicinees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/COV20/1144es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/CP14CIII/00010es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/CP17CIII/00007es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/CP19CIII/00002es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/MPY224/20es_ES


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Atribución 4.0 Internacional
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