Mostrar el registro sencillo del ítem
dc.contributor.author | Fehér, Csaba | |
dc.contributor.author | Pastor-Ibáñez, Roque | |
dc.contributor.author | Leal, Lorna | |
dc.contributor.author | Plana, Montserrat | |
dc.contributor.author | Arnedo, Mireia | |
dc.contributor.author | van den Ham, Henk-Jan | |
dc.contributor.author | Andeweg, Arno C | |
dc.contributor.author | Gruters, Rob A | |
dc.contributor.author | Díez-Fuertes, Francisco | |
dc.contributor.author | Alcamí, José | |
dc.contributor.author | Aloy, Patrick | |
dc.contributor.author | García, Felipe | |
dc.date.accessioned | 2022-04-22T15:47:49Z | |
dc.date.available | 2022-04-22T15:47:49Z | |
dc.date.issued | 2021-07-19 | |
dc.identifier.citation | Vaccines (Basel). 2021;9(7):799. | es_ES |
dc.identifier.issn | 2076-393X | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/14160 | |
dc.description.abstract | Systems vaccinology has seldomly been used in therapeutic HIV-1 vaccine research. Our aim was to identify early gene 'signatures' that predicted virus load control after analytical therapy interruption (ATI) in participants of a dendritic cell-based HIV-1 vaccine trial (DCV2). mRNA and miRNA were extracted from frozen post-vaccination PBMC samples; gene expression was determined by microarray method. In gene set enrichment analysis, responders showed an up-regulation of 14 gene sets (TNF-alpha/NFkB pathway, inflammatory response, the complement system, Il6 and Il2 JAK-STAT signaling, among others) and a down-regulation of 7 gene sets (such as E2F targets or interferon alpha response). The expression of genes regulated by three (miR-223-3p, miR-1183 and miR-8063) of the 9 differentially expressed miRNAs was significantly down-regulated in responders. The deregulation of certain gene sets related to inflammatory processes seems fundamental for viral control, and certain miRNAs may be important in fine-tuning these processes. | es_ES |
dc.description.sponsorship | This study was supported by the European Commission (grants: H2020-SC1-2016-RTD Proposal: 731626), the Spanish Ministry of Economy (MINECO) (grants: SAF2015-66193-R, RTI2018-096309-B-I00), the Fondo de Investigación Sanitaria (FIS) PI15/00480, AC16/00051, and PI18/00699, amfAR Grant # 108821-55-RGRL, the Fondo Europeo para el Desarrollo Regional (FEDER), the SPANISH AIDS Research Network RD16/0025/0002–ISCIII–FEDER (RIS), and the CERCA Program/Generalitat de Catalunya SGR 615. F.G. has received the support of José María Segovia de Arana contracts. C.F. held a fellowship from “PhD4MD,” a Collaborative Research Training Programme for Medical Doctors financed by IRB Barcelona (Institute for Research in Biomedicine) and IDIBAPS (August Pi i Sunyer Biomedical Research Institute) during the study. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Dendritic cell-based therapeutic HIV-1 vaccine | es_ES |
dc.subject | Differential gene expression | es_ES |
dc.subject | Gene set enrichment analysis | es_ES |
dc.subject | miRNA | es_ES |
dc.subject | mMRA | es_ES |
dc.title | Association of Transcriptomic Signatures of Inflammatory Response with Viral Control after Dendritic Cell-Based Therapeutic Vaccination in HIV-1 Infected Individuals | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 34358215 | es_ES |
dc.format.volume | 9 | es_ES |
dc.format.number | 7 | es_ES |
dc.format.page | 799 | es_ES |
dc.identifier.doi | 10.3390/vaccines9070799 | es_ES |
dc.contributor.funder | Government of Catalonia (España) | es_ES |
dc.contributor.funder | Red de Investigación Cooperativa en Investigación en Sida (España) | es_ES |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | es_ES |
dc.contributor.funder | Ministerio de Economía (España) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/vaccines9070799 | es_ES |
dc.identifier.journal | Vaccines | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/731626/EU | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/108821-55-RGRL | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/MINECO//SAF2015-66193-R/ES/UTILIZACION DE MEDICINA DE SISTEMAS PARA LA PREDICCION DE LA INMUNOGENICIDAD Y EFICACIA DE VACUNAS TERAPEUTICAS FRENTE A VIH/ | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/RTI2018-096309-B-I00 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/MINECO//RD16%2F0025%2F0002/ES/RED ESPAÑOLA DE INVESTIGACIÓN EN SIDA (RIS)/ | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/null/null/Subprograma de proyectos de investigacion en salud (AES 2015). Modalidad proyectos en salud. (2015)/PI15/00480 | es_ES |
dc.relation.projectFIS | info:fis/Instituto de Salud Carlos III/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/Subprograma Estatal de Generación de Conocimiento/PI18 - Proyectos de investigacion en salud (AES 2018). Modalidad proyectos en salud. (2018)/PI18/00699 | es_ES |
dc.relation.projectFIS | info:eu-repo/grantAgreement/ES/AC16/00051 | es_ES |