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dc.contributor.authorBiosca-Brull, Judit
dc.contributor.authorPérez-Fernández, Cristian
dc.contributor.authorMora, Santiago
dc.contributor.authorCarrillo, Beatriz
dc.contributor.authorPinos, Helena
dc.contributor.authorConejo, Nelida Maria
dc.contributor.authorCollado, Paloma
dc.contributor.authorArias, Jorge L
dc.contributor.authorMartin-Sanchez, Fernando 
dc.contributor.authorSánchez-Santed, Fernando
dc.contributor.authorColomina, Maria Teresa
dc.date.accessioned2022-03-28T11:09:03Z
dc.date.available2022-03-28T11:09:03Z
dc.date.issued2021-05-13
dc.identifier.citationInt J Environ Res Public Health. 2021 May 13;18(10):5190.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/13861
dc.description.abstractAutism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.es_ES
dc.description.sponsorshipThe study was supported by grants from the Spanish Goverment (Ministerio de Economía y Competitividad, Ministerio de Ciencia, Innovación y Universidades and Instituto Mixto de Investigación-Escuela Nacional de Sanidad (IMIENS)) and the Fondo Europeo de Desarrollo Regional (MINECO-FEDER) [Grant numbers: PSI2017-86847-C2-1-R MINECO-FEDER, PSI2017-86847-C2-2-R, PSI2017-86396-P, PSI2017-90806-REDT, PSI2013-45924-P, PSI2017-83038-P, PSI2017-83893-R, MINECO PSI2017-86396-P and IMIENS: PIC-IMIENS-2018-003].es_ES
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAutism spectrum disorderes_ES
dc.subjectSociabilityes_ES
dc.subjectPesticidees_ES
dc.subjectOrganophosphatees_ES
dc.subjectCarbamateses_ES
dc.subjectOrganochlorinees_ES
dc.subjectChlorpyrifoses_ES
dc.titleRelationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Modelses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID34068255es_ES
dc.format.volume18es_ES
dc.format.number10es_ES
dc.identifier.doi10.3390/ijerph18105190es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderInstituto de Salud Carlos III es_ES
dc.contributor.funderEuropean Regional Development Fund es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1660-4601es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/ijerph18105190es_ES
dc.identifier.journalInternational Journal of Environmental Research And Public Healthes_ES
dc.repisalud.centroISCIII::Escuela Nacional de Sanidades_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PSI2017-86847-C2-1-Res_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PSI2017-86847-C2-2-Res_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PSI2017-86396-Pes_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PSI2017-90806-REDTes_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PSI2013-45924-Pes_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PSI2017-83038-Pes_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PSI2017-83893-Res_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PSI2017-86396-Pes_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/PIC-IMIENS-2018-003es_ES


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