Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/13851
Título
Symptomatic and Asymptomatic Protist Infections in Hospital Inpatients in Southwestern China
Autor(es)
Zhang, Shun-Xian | Carmena, David ISCIII | Ballesteros, Cristina | Yang, Chun-Li | Chen, Jia-Xu | Chu, Yan-Hong | Yu, Ying-Fang | Wu, Xiu-Ping | Tian, Li-Guang | Serrano Ferron, Emmanuel ISCIII
Fecha de publicación
2021-05
Cita
Pathogens. 2021 May 31;10(6):684.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Cryptosporidium spp., Entamoeba histolytica, Giardia duodenalis, and Blastocystis sp. infections have been frequently reported as etiological agents for gastroenteritis, but also as common gut inhabitants in apparently healthy individuals. Between July 2016 and March 2017, stool samples (n = 507) were collected from randomly selected individuals (male/female ratio: 1.1, age range: 38-63 years) from two sentinel hospitals in Tengchong City Yunnan Province, China. Molecular (PCR and Sanger sequencing) methods were used to detect and genotype the investigated protist species. Carriage/infection rates were: Blastocystis sp. 9.5% (95% CI: 7.1-12.4%), G. duodenalis 2.2% (95% CI: 1.1-3.8%); and E. histolytica 2.0% (95% CI: 0.9-3.6%). Cryptosporidium spp. was not detected at all. Overall, 12.4% (95% CI: 9.7-15.6) of the participants harbored at least one enteric protist species. The most common coinfection was E. histolytica and Blastocystis sp. (1.0%; 95% CI: 0.3-2.2). Sequence analyses revealed that 90.9% (10/11) of the genotyped G. duodenalis isolates corresponded to the sub-assemblage AI. The remaining sequence (9.1%, 1/11) was identified as sub-assemblage BIV. Five different Blastocystis subtypes, including ST3 (43.7%, 21/48), ST1 (27.1%, 13/48), ST7 (18.8%, 9/48), ST4 (8.3%, 4/48), and ST2 (2.1%, 1/48) were identified. Statistical analyses confirmed that (i) the co-occurrence of protist infections was purely random, (ii) no associations were observed among the four protist species found, and (iii) neither their presence, individually or jointly, nor the patient's age was predictors for developing clinical symptoms associated with these infections. Overall, these protist mono- or coinfections are asymptomatic and do not follow any pattern.
Palabras clave
Coinfection | Enteric protists | China | Giardia duodenalis | Entamoeba histolytica | Cryptosporidium | Blastocystis sp. | Genotyping | Molecular diversity
Versión en línea
DOI
Aparece en las colecciones
Ficheros en el ítem
![Acceso Abierto Acceso Abierto](/themes/Mirage2/images/openAccess.png)
- Nombre:
- SymptomaticAndAsymptomaticProt ...
- Tamaño:
- 248.5Kb
- Formato:
- Descripción:
- Artículo principal
![Acceso Abierto Acceso Abierto](/themes/Mirage2/images/openAccess.png)
- Nombre:
- SymptomaticAndAsymptomaticProt ...
- Tamaño:
- 146.9Kb
- Formato:
- Descripción:
- Supplementary data