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dc.contributor.author | Amodio, Giada | |
dc.contributor.author | Cichy, Joanna | |
dc.contributor.author | Conde-San Román, Patricia | |
dc.contributor.author | Matteoli, Gianluca | |
dc.contributor.author | Moreau, Aurélie | |
dc.contributor.author | Ochando, Jordi | |
dc.contributor.author | Oral, Barbaros H | |
dc.contributor.author | Pekarova, Michaela | |
dc.contributor.author | Ryan, Elizabeth J | |
dc.contributor.author | Roth, Johannes | |
dc.contributor.author | Sohrabi, Yahya | |
dc.contributor.author | Cuturi, Maria-Cristina | |
dc.contributor.author | Gregori, Silvia | |
dc.date.accessioned | 2022-03-25T13:46:17Z | |
dc.date.available | 2022-03-25T13:46:17Z | |
dc.date.issued | 2019-04 | |
dc.identifier.citation | Cancer Immunol Immunother. 2019 Apr;68(4):661-672. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/13827 | |
dc.description | This paper is part of a Symposium-in-Writing in Cancer Immunology, Immunotherapy by members of the European Network of Investigators Triggering Exploratory Research on Myeloid Regulatory Cells (Mye-EUNITER network), funded by the COST programme of the European Union (http://www.mye-euniter.eu). | es_ES |
dc.description.abstract | Myeloid cells play a pivotal role in regulating innate and adaptive immune responses. In inflammation, autoimmunity, and after transplantation, myeloid cells have contrasting roles: on the one hand they initiate the immune response, promoting activation and expansion of effector T-cells, and on the other, they counter-regulate inflammation, maintain tissue homeostasis, and promote tolerance. The latter activities are mediated by several myeloid cells including polymorphonuclear neutrophils, macrophages, myeloid-derived suppressor cells, and dendritic cells. Since these cells have been associated with immune suppression and tolerance, they will be further referred to as myeloid regulatory cells (MRCs). In recent years, MRCs have emerged as a therapeutic target or have been regarded as a potential cellular therapeutic product for tolerance induction. However, several open questions must be addressed to enable the therapeutic application of MRCs including: how do they function at the site of inflammation, how to best target these cells to modulate their activities, and how to isolate or to generate pure populations for adoptive cell therapies. In this review, we will give an overview of the current knowledge on MRCs in inflammation, autoimmunity, and transplantation. We will discuss current strategies to target MRCs and to exploit their tolerogenic potential as a cell-based therapy. | es_ES |
dc.description.sponsorship | This work was supported by COST (European Cooperation in Science and Technology) and the COST Action BM1404 Mye-EUNITER (https://www.mye-euniter.eu). COST is part of the EU Framework Programme Horizon 2020. H. Barbaros Oral is supported by The Scientific and Technical Research Council of Turkey (TUBITAK) (Project no: 114S354). Elizabeth J. Ryan is supported by the Irish Health Research Board (#POR-2013-281). Joanna Cichy was supported by Polish National Science Center grant 2011/02/A/NZ5/00337. Michaela Pekarova was supported by the Ministry of Education, Youth and Sports (no. LTAUSA17160). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Dendritic cells | es_ES |
dc.subject | Monocytes/macrophages | es_ES |
dc.subject | Mye-EUNITER | es_ES |
dc.subject | Myeloid regulatory cells (MRCs) | es_ES |
dc.subject | Polymorphonuclear neutrophils | es_ES |
dc.subject | Tolerance | es_ES |
dc.subject.mesh | Autoimmunity | es_ES |
dc.subject.mesh | Homeostasis | es_ES |
dc.subject.mesh | Immune Tolerance | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Biomarkers | es_ES |
dc.subject.mesh | Disease Susceptibility | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Immunomodulation | es_ES |
dc.subject.mesh | Immunophenotyping | es_ES |
dc.subject.mesh | Inflammation | es_ES |
dc.subject.mesh | Macrophages | es_ES |
dc.subject.mesh | Monocytes | es_ES |
dc.subject.mesh | Myeloid Cells | es_ES |
dc.subject.mesh | Neutrophils | es_ES |
dc.subject.mesh | Organ Transplantation | es_ES |
dc.subject.mesh | T-Lymphocyte Subsets | es_ES |
dc.subject.mesh | Transplantation, Homologous | es_ES |
dc.title | Role of myeloid regulatory cells (MRCs) in maintaining tissue homeostasis and promoting tolerance in autoimmunity, inflammatory disease and transplantation | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 30357490 | es_ES |
dc.format.volume | 68 | es_ES |
dc.format.number | 4 | es_ES |
dc.format.page | 661-672 | es_ES |
dc.identifier.doi | 10.1007/s00262-018-2264-3 | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea. H2020 | es_ES |
dc.contributor.funder | Unión Europea. European Cooperation in Science and Technology (COST) | es_ES |
dc.contributor.funder | Scientific and Technological Research Council of Turkey | es_ES |
dc.contributor.funder | National Science Centre (Polonia) | es_ES |
dc.contributor.funder | Health Research Board (Irlanda) | es_ES |
dc.contributor.funder | Ministry of Education, Youth and Sports (República Checa) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1432-0851 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1007/s00262-018-2264-3 | es_ES |
dc.identifier.journal | Cancer Immunology, Immunotherapy: CII | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/BM1404 | es_ES |
dc.rights.accessRights | open access | es_ES |