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dc.contributor.authorAmodio, Giada
dc.contributor.authorCichy, Joanna
dc.contributor.authorConde-San Román, Patricia 
dc.contributor.authorMatteoli, Gianluca
dc.contributor.authorMoreau, Aurélie
dc.contributor.authorOchando, Jordi 
dc.contributor.authorOral, Barbaros H
dc.contributor.authorPekarova, Michaela
dc.contributor.authorRyan, Elizabeth J
dc.contributor.authorRoth, Johannes
dc.contributor.authorSohrabi, Yahya
dc.contributor.authorCuturi, Maria-Cristina
dc.contributor.authorGregori, Silvia
dc.date.accessioned2022-03-25T13:46:17Z
dc.date.available2022-03-25T13:46:17Z
dc.date.issued2019-04
dc.identifier.citationCancer Immunol Immunother. 2019 Apr;68(4):661-672.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/13827
dc.descriptionThis paper is part of a Symposium-in-Writing in Cancer Immunology, Immunotherapy by members of the European Network of Investigators Triggering Exploratory Research on Myeloid Regulatory Cells (Mye-EUNITER network), funded by the COST programme of the European Union (http://www.mye-euniter.eu).es_ES
dc.description.abstractMyeloid cells play a pivotal role in regulating innate and adaptive immune responses. In inflammation, autoimmunity, and after transplantation, myeloid cells have contrasting roles: on the one hand they initiate the immune response, promoting activation and expansion of effector T-cells, and on the other, they counter-regulate inflammation, maintain tissue homeostasis, and promote tolerance. The latter activities are mediated by several myeloid cells including polymorphonuclear neutrophils, macrophages, myeloid-derived suppressor cells, and dendritic cells. Since these cells have been associated with immune suppression and tolerance, they will be further referred to as myeloid regulatory cells (MRCs). In recent years, MRCs have emerged as a therapeutic target or have been regarded as a potential cellular therapeutic product for tolerance induction. However, several open questions must be addressed to enable the therapeutic application of MRCs including: how do they function at the site of inflammation, how to best target these cells to modulate their activities, and how to isolate or to generate pure populations for adoptive cell therapies. In this review, we will give an overview of the current knowledge on MRCs in inflammation, autoimmunity, and transplantation. We will discuss current strategies to target MRCs and to exploit their tolerogenic potential as a cell-based therapy.es_ES
dc.description.sponsorshipThis work was supported by COST (European Cooperation in Science and Technology) and the COST Action BM1404 Mye-EUNITER (https://www.mye-euniter.eu). COST is part of the EU Framework Programme Horizon 2020. H. Barbaros Oral is supported by The Scientific and Technical Research Council of Turkey (TUBITAK) (Project no: 114S354). Elizabeth J. Ryan is supported by the Irish Health Research Board (#POR-2013-281). Joanna Cichy was supported by Polish National Science Center grant 2011/02/A/NZ5/00337. Michaela Pekarova was supported by the Ministry of Education, Youth and Sports (no. LTAUSA17160).es_ES
dc.language.isoenges_ES
dc.publisherSpringer es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectDendritic cellses_ES
dc.subjectMonocytes/macrophageses_ES
dc.subjectMye-EUNITERes_ES
dc.subjectMyeloid regulatory cells (MRCs)es_ES
dc.subjectPolymorphonuclear neutrophilses_ES
dc.subjectTolerancees_ES
dc.subject.meshAutoimmunity es_ES
dc.subject.meshHomeostasis es_ES
dc.subject.meshImmune Tolerance es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshBiomarkers es_ES
dc.subject.meshDisease Susceptibility es_ES
dc.subject.meshHumans es_ES
dc.subject.meshImmunomodulation es_ES
dc.subject.meshImmunophenotyping es_ES
dc.subject.meshInflammation es_ES
dc.subject.meshMacrophages es_ES
dc.subject.meshMonocytes es_ES
dc.subject.meshMyeloid Cells es_ES
dc.subject.meshNeutrophils es_ES
dc.subject.meshOrgan Transplantation es_ES
dc.subject.meshT-Lymphocyte Subsets es_ES
dc.subject.meshTransplantation, Homologous es_ES
dc.titleRole of myeloid regulatory cells (MRCs) in maintaining tissue homeostasis and promoting tolerance in autoimmunity, inflammatory disease and transplantationes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30357490es_ES
dc.format.volume68es_ES
dc.format.number4es_ES
dc.format.page661-672es_ES
dc.identifier.doi10.1007/s00262-018-2264-3es_ES
dc.contributor.funderUnión Europea. Comisión Europea. H2020 es_ES
dc.contributor.funderUnión Europea. European Cooperation in Science and Technology (COST) es_ES
dc.contributor.funderScientific and Technological Research Council of Turkey es_ES
dc.contributor.funderNational Science Centre (Polonia) es_ES
dc.contributor.funderHealth Research Board (Irlanda) es_ES
dc.contributor.funderMinistry of Education, Youth and Sports (República Checa) es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1432-0851es_ES
dc.relation.publisherversionhttps://doi.org/10.1007/s00262-018-2264-3es_ES
dc.identifier.journalCancer Immunology, Immunotherapy: CIIes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/BM1404es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional