dc.contributor.author | Casquero-Veiga, Marta | |
dc.contributor.author | Bueno-Fernandez, Clara | |
dc.contributor.author | Romero-Miguel, Diego | |
dc.contributor.author | Lamanna-Rama, Nicolas | |
dc.contributor.author | Nacher, Juan | |
dc.contributor.author | Desco, Manuel | |
dc.contributor.author | Soto-Montenegro, Maria Luisa | |
dc.date.accessioned | 2021-09-15T06:37:37Z | |
dc.date.available | 2021-09-15T06:37:37Z | |
dc.date.issued | 2021-03-10 | |
dc.identifier.citation | Sci Rep. 2021; 11(1):5580 | es_ES |
dc.identifier.issn | 2045-2322 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/13389 | |
dc.description.abstract | Deep brain stimulation (DBS) is a powerful neurostimulation therapy proposed for the treatment of several neuropsychiatric disorders. However, DBS mechanism of action remains unclear, being its effects on brain dynamics of particular interest. Specifically, DBS reversibility is a major point of debate. Preclinical studies in obesity showed that the stimulation of the lateral hypothalamus (LH) and nucleus accumbens (NAcc), brain centers involved in satiety and reward circuits, are able to modulate the activity of brain structures impaired in this pathology. Nevertheless, the long-term persistence of this modulation after DBS withdrawal was unexplored. Here we examine the in vivo presence of such changes 1 month after LH- and NAcc-DBS, along with differences in synaptic plasticity, following an exploratory approach. Thus, both stimulated and non-stimulated animals with electrodes in the NAcc showed a common pattern of brain metabolism modulation, presumably derived from the electrodes' presence. In contrast, animals stimulated in the LH showed a relative metabolic invariance, and a reduction of neuroplasticity molecules, evidencing long-lasting neural changes. Our findings suggest that the reversibility or persistence of DBS modulation in the long-term depends on the selected DBS target. Therefore, the DBS footprint would be influenced by the stability achieved in the neural network involved during the stimulation. | es_ES |
dc.description.sponsorship | This research was supported by the Ministerio de Ciencia, Innovación y Universidades, Instituto de Salud Carlos III (projects PI14/00860 and PI17/01766, and grant CPII14/00005), co-financed by European Regional Development Fund (ERDF), “A way of making Europe”, CIBERSAM, Delegación del Gobierno para el Plan Nacional sobre Drogas (2017/085), Fundación Mapfre and Fundación Alicia Koplowitz. MCV was supported by Fundación Tatiana Pérez de Guzmán el Bueno as scholarship holder of this institution. DRM was supported by Consejería de Educación e Investigación, Comunidad de Madrid, co-funded by European Social Fund “Investing in your future” (grant, PEJD-2018-PRE/BMD-7899). NLR was supported by Instituto de Investigación Sanitaria Gregorio Marañón, "Programa Intramural de Impulso a la I+D+I 2019”. The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV‐2015‐0505). Support for Nacher’s lab came from Ministry of Economy and Competitiveness (SAF2015-68436-R), Generalitat Valenciana (PROMETEO2013/069) and Fundación Alicia Koplowitz (FAK2012/01). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Exploratory study of the long-term footprint of deep brain stimulation on brain metabolism and neuroplasticity in an animal model of obesity. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 33692388 | es_ES |
dc.format.volume | 11 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 5580 | es_ES |
dc.identifier.doi | 10.1038/s41598-021-82987-7 | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Fundación Mapfre | |
dc.contributor.funder | Fundación Alicia Koplowitz | |
dc.contributor.funder | Fundación Tatiana Pérez de Guzmán el Bueno | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Instituto de Investigación Sanitaria Gregorio Marañón | |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Generalitat Valenciana (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/s41598-021-82987-7 | es_ES |
dc.identifier.journal | Scientific reports | es_ES |
dc.repisalud.orgCNIC | CNIC::Unidades técnicas::Imagen Avanzada | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/PEJD-2018-PRE/BMD-7899 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI14/00860 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PI17/01766 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/CPII14/00005 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/2017/085 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SEV‐2015‐0505 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/SAF2015-68436-R | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/PROMETEO2013/069 | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/ES/FAK2012/01 | es_ES |