Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/13389
Título
Exploratory study of the long-term footprint of deep brain stimulation on brain metabolism and neuroplasticity in an animal model of obesity.
Autor(es)
Fecha de publicación
2021-03-10
Cita
Sci Rep. 2021; 11(1):5580
Idioma
Inglés
Tipo de documento
journal article
Resumen
Deep brain stimulation (DBS) is a powerful neurostimulation therapy proposed for the treatment of several neuropsychiatric disorders. However, DBS mechanism of action remains unclear, being its effects on brain dynamics of particular interest. Specifically, DBS reversibility is a major point of debate. Preclinical studies in obesity showed that the stimulation of the lateral hypothalamus (LH) and nucleus accumbens (NAcc), brain centers involved in satiety and reward circuits, are able to modulate the activity of brain structures impaired in this pathology. Nevertheless, the long-term persistence of this modulation after DBS withdrawal was unexplored. Here we examine the in vivo presence of such changes 1 month after LH- and NAcc-DBS, along with differences in synaptic plasticity, following an exploratory approach. Thus, both stimulated and non-stimulated animals with electrodes in the NAcc showed a common pattern of brain metabolism modulation, presumably derived from the electrodes' presence. In contrast, animals stimulated in the LH showed a relative metabolic invariance, and a reduction of neuroplasticity molecules, evidencing long-lasting neural changes. Our findings suggest that the reversibility or persistence of DBS modulation in the long-term depends on the selected DBS target. Therefore, the DBS footprint would be influenced by the stability achieved in the neural network involved during the stimulation.
Versión en línea
DOI
Aparece en las colecciones
- Investigación > IIS > INCLIVA - Instituto de Investigación Sanitaria Fundación para la Investigación del Hospital Clínico de Valencia (C. Valenciana)
- Investigación > IIS > IiSGM - Instituto de Investigación Sanitaria Gregorio Marañón (Madrid)
- Investigación > CNIC > Unidades técnicas > CNIC - Artículos
Ficheros en el ítem
- Nombre:
- ExploratoryStudyofThe_2021.pdf
- Tamaño:
- 1.894Mb
- Formato:
- Descripción:
- Artículo
- Nombre:
- ExploratoryStudyofThe_2021_supp.pdf
- Tamaño:
- 327.0Kb
- Formato:
- Descripción:
- Additional data file 1