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dc.contributor.authorCecconi, Alberto
dc.contributor.authorVilchez-Tschischke, Jean Paul
dc.contributor.authorMateo, Jesus 
dc.contributor.authorSanchez-Gonzalez, Javier 
dc.contributor.authorEspana, Samuel 
dc.contributor.authorFernandez-Jimenez, Rodrigo 
dc.contributor.authorLopez-Melgar, Beatriz 
dc.contributor.authorFernandez-Friera, Leticia 
dc.contributor.authorLopez-Martin, Gonzalo J. 
dc.contributor.authorFuster, Valentin 
dc.contributor.authorRuiz-Cabello, Jesus 
dc.contributor.authorIbáñez, Borja 
dc.date.accessioned2021-09-13T11:14:19Z
dc.date.available2021-03-01T11:14:19Z
dc.date.issued2021-02
dc.identifier.citationJ Cardiovasc Transl Res. 2021; 14(1):150-60es_ES
dc.identifier.issn1937-5395es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/13380
dc.description.abstractColchicine demonstrated clinical benefits in the treatment of stable coronary artery disease. Our aim was to evaluate the effects of colchicine on atherosclerotic plaque stabilization. Atherosclerosis was induced in the abdominal aorta of 20 rabbits with high-cholesterol diet and balloon endothelial denudation. Rabbits were randomized to receive either colchicine or placebo. All animals underwent MRI, 18F-FDG PET/CT, optical coherence tomography (OCT), and histology. Similar progression of atherosclerotic burden was observed in the two groups as relative increase of normalized wall index (NWI). Maximum 18F-FDG standardized uptake value (meanSUVmax) decreased after colchicine treatment, while it increased in the placebo group with a trend toward significance. Animals with higher levels of cholesterol showed significant differences in favor to colchicine group, both as NWI at the end of the protocol and as relative increase in meanSUVmax. Colchicine may stabilize atherosclerotic plaque by reducing inflammatory activity and plaque burden, without altering macrophage infiltration or plaque typology.es_ES
dc.description.sponsorshipThis work was supported by a grant from the Sociedad Española de Cardiología, a grant from the Instituto de Salud Carlos III of Spain and Fondo Europeo de Desarrollo Regional (FEDER, “Una manera de hacer Europa”) (FIS-FEDER PI14-01427 to J. Mateo) and a grant from Fundación BBVA to J. Ruiz-Cabello. The CNIC is supported by the Instituto de Salud Carlos III, the Ministry of Science and Innovation and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). CIC biomaGUNE is supported by the Spanish State Research Agency of MICIN under the María de Maeztu Units of Excellence Program from MDM-2017-0720.es_ES
dc.language.isoenges_ES
dc.publisherSpringer es_ES
dc.type.hasVersionAMes_ES
dc.titleEffects of Colchicine on Atherosclerotic Plaque Stabilization: a Multimodality Imaging Study in an Animal Model.es_ES
dc.typejournal articlees_ES
dc.identifier.pubmedID32140929es_ES
dc.format.volume14es_ES
dc.format.number1es_ES
dc.format.page150-160es_ES
dc.identifier.doi10.1007/s12265-020-09974-7es_ES
dc.contributor.funderSociedad Española de Cardiología 
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderFundación BBVA 
dc.contributor.funderMinisterio de Ciencia e Innovación (España) 
dc.contributor.funderFundación ProCNIC 
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1007/s12265-020-09974-7es_ES
dc.identifier.journalJournal of cardiovascular translational researches_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovasculares_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Imagen Avanzadaes_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsopen accesses_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectFECYTinfo:eu-repo/grantAgreement/ES/MDM-2017-0720es_ES
dc.relation.projectFISinfo:eu-repo/grantAgreement/ES/FIS-FEDER-PI14-01427es_ES


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