Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/13380
Effects of Colchicine on Atherosclerotic Plaque Stabilization: a Multimodality Imaging Study in an Animal Model.
Cecconi, Alberto | Vilchez-Tschischke, Jean Paul | Mateo, Jesus CNIC | Sanchez-Gonzalez, Javier CNIC | Espana, Samuel CNIC | Fernandez-Jimenez, Rodrigo CNIC | Lopez-Melgar, Beatriz CNIC | Fernandez-Friera, Leticia CNIC | Lopez-Martin, Gonzalo J. CNIC | Fuster, Valentin CNIC | Ruiz-Cabello, Jesus CNIC | Ibanez, Borja CNIC
J Cardiovasc Transl Res. 2021; 14(1):150-60
Colchicine demonstrated clinical benefits in the treatment of stable coronary artery disease. Our aim was to evaluate the effects of colchicine on atherosclerotic plaque stabilization. Atherosclerosis was induced in the abdominal aorta of 20 rabbits with high-cholesterol diet and balloon endothelial denudation. Rabbits were randomized to receive either colchicine or placebo. All animals underwent MRI, 18F-FDG PET/CT, optical coherence tomography (OCT), and histology. Similar progression of atherosclerotic burden was observed in the two groups as relative increase of normalized wall index (NWI). Maximum 18F-FDG standardized uptake value (meanSUVmax) decreased after colchicine treatment, while it increased in the placebo group with a trend toward significance. Animals with higher levels of cholesterol showed significant differences in favor to colchicine group, both as NWI at the end of the protocol and as relative increase in meanSUVmax. Colchicine may stabilize atherosclerotic plaque by reducing inflammatory activity and plaque burden, without altering macrophage infiltration or plaque typology.
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