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dc.contributor.author | Monsalve-Castillo, Francisca | |
dc.contributor.author | Chacín-Bonilla, Leonor | |
dc.contributor.author | Atencio, Ricardo J | |
dc.contributor.author | Espinoza, Leticia Porto | |
dc.contributor.author | Costa-León, Luciana | |
dc.contributor.author | Echevarria, Jose Manuel | |
dc.date.accessioned | 2021-05-06T18:03:07Z | |
dc.date.available | 2021-05-06T18:03:07Z | |
dc.date.issued | 2007-02 | |
dc.identifier.citation | Mem Inst Oswaldo Cruz . 2007 Feb;102(1):107-10 | es_ES |
dc.identifier.issn | 0074-0276 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/12895 | |
dc.description.abstract | Previous studies have not found hepatitis C virus (HCV) infection in Amerindians from Western Venezuela. A survey of 254 Bari and Yukpa natives aged 10-60 years (mean +/- SD age = 35 +/- 5.4 years) from four communities, two Bari and two Yukpa, in this area were studied to assess the prevalence of antibodies to HCV (anti-HCV) and HCV RNA among these indigenous populations. Serum samples were examined initially for anti-HCV by a four generation enzyme-linked immunosorbent assay (ELISA). Reactive samples were then tested using a third generation recombinant immunoblot assay (RIBA-3). Viral RNA was investigated in all immunoblot-reactive samples by a nested polymerase chain reaction (PCR) method. Six (2.3%) of 254 natives were positive by ELISA, one (2.2%) of these reactive samples were positive by RIBA, and four (1.5%) were indeterminate. Only two (0.8%) were positive by PCR, corresponding to 1 (2.1%) of 47 inhabitants of a Yukpa community and to 1 (2.2%) of 45 subjects of a Bari community. Iatrogenic is thought to play a role in acquisition of the infection. The findings indicate a HCV focus of low endemicity and are compatible with a low degree of exposures of the natives to the virus. Studies are necessary to assess the risk factors for infection in these Amerindians. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Fundação Oswaldo Cruz (Fiocruz) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | hepatitis C virus | es_ES |
dc.subject | prevalence | es_ES |
dc.subject | Amerindians | es_ES |
dc.subject | Venezuela | es_ES |
dc.subject.mesh | Indians, South American | es_ES |
dc.subject.mesh | Adolescent | es_ES |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Child | es_ES |
dc.subject.mesh | Enzyme-Linked Immunosorbent Assay | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Hepacivirus | es_ES |
dc.subject.mesh | Hepatitis C | es_ES |
dc.subject.mesh | Hepatitis C Antibodies | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Polymerase Chain Reaction | es_ES |
dc.subject.mesh | Prevalence | es_ES |
dc.subject.mesh | RNA, Viral | es_ES |
dc.subject.mesh | Venezuela | es_ES |
dc.title | Low prevalence of hepatitis C virus infection in Amerindians from Western Venezuela. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución-NoComercial 4.0 Internacional | * |
dc.identifier.pubmedID | 17294009 | es_ES |
dc.format.volume | 102 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 107-10 | es_ES |
dc.identifier.doi | 10.1590/s0074-02762007000100018 | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://memorias.ioc.fiocruz.br/article/1133/low-prevalence-of-hepatitis-c-virus-infection-in-amerindians-from-western-venezuela | es_ES |
dc.identifier.journal | Memorias do Instituto Oswaldo Cruz | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |