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dc.contributor.authorMonsalve-Castillo, Francisca
dc.contributor.authorChacín-Bonilla, Leonor
dc.contributor.authorAtencio, Ricardo J
dc.contributor.authorEspinoza, Leticia Porto
dc.contributor.authorCosta-León, Luciana
dc.contributor.authorEchevarría, Jose Manuel 
dc.date.accessioned2021-05-06T18:03:07Z
dc.date.available2021-05-06T18:03:07Z
dc.date.issued2007-02
dc.identifier.citationMem Inst Oswaldo Cruz . 2007 Feb;102(1):107-10es_ES
dc.identifier.issn0074-0276es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/12895
dc.description.abstractPrevious studies have not found hepatitis C virus (HCV) infection in Amerindians from Western Venezuela. A survey of 254 Bari and Yukpa natives aged 10-60 years (mean +/- SD age = 35 +/- 5.4 years) from four communities, two Bari and two Yukpa, in this area were studied to assess the prevalence of antibodies to HCV (anti-HCV) and HCV RNA among these indigenous populations. Serum samples were examined initially for anti-HCV by a four generation enzyme-linked immunosorbent assay (ELISA). Reactive samples were then tested using a third generation recombinant immunoblot assay (RIBA-3). Viral RNA was investigated in all immunoblot-reactive samples by a nested polymerase chain reaction (PCR) method. Six (2.3%) of 254 natives were positive by ELISA, one (2.2%) of these reactive samples were positive by RIBA, and four (1.5%) were indeterminate. Only two (0.8%) were positive by PCR, corresponding to 1 (2.1%) of 47 inhabitants of a Yukpa community and to 1 (2.2%) of 45 subjects of a Bari community. Iatrogenic is thought to play a role in acquisition of the infection. The findings indicate a HCV focus of low endemicity and are compatible with a low degree of exposures of the natives to the virus. Studies are necessary to assess the risk factors for infection in these Amerindians.es_ES
dc.language.isoenges_ES
dc.publisherFundação Oswaldo Cruzes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjecthepatitis C viruses_ES
dc.subjectprevalencees_ES
dc.subjectAmerindianses_ES
dc.subjectVenezuelaes_ES
dc.subject.meshIndians, South Americanes_ES
dc.subject.meshAdolescent es_ES
dc.subject.meshAdult es_ES
dc.subject.meshChild es_ES
dc.subject.meshEnzyme-Linked Immunosorbent Assay es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHepacivirus es_ES
dc.subject.meshHepatitis C es_ES
dc.subject.meshHepatitis C Antibodies es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshPolymerase Chain Reaction es_ES
dc.subject.meshPrevalence es_ES
dc.subject.meshRNA, Viral es_ES
dc.subject.meshVenezuela es_ES
dc.titleLow prevalence of hepatitis C virus infection in Amerindians from Western Venezuela.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial 4.0 Internacional*
dc.identifier.pubmedID17294009es_ES
dc.format.volume102es_ES
dc.format.number1es_ES
dc.format.page107-10es_ES
dc.identifier.doi10.1590/s0074-02762007000100018es_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://memorias.ioc.fiocruz.br/article/1133/low-prevalence-of-hepatitis-c-virus-infection-in-amerindians-from-western-venezuelaes_ES
dc.identifier.journalMemorias do Instituto Oswaldo Cruzes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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