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dc.contributor.author | Cantón-Habas, Vanesa | |
dc.contributor.author | Rich-Ruiz, Manuel | |
dc.contributor.author | Moreno-Casbas, Teresa | |
dc.contributor.author | Ramírez-Expósito, María Jesús | |
dc.contributor.author | Martínez-Martos, Jose Manuel | |
dc.contributor.author | Carrera-González, María Del Pilar | |
dc.date.accessioned | 2021-05-05T12:24:37Z | |
dc.date.available | 2021-05-05T12:24:37Z | |
dc.date.issued | 2021-04-01 | |
dc.identifier.citation | J Clin Med . 2021 Apr 1;10(7):1424. | es_ES |
dc.identifier.issn | 2077-0383 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/12877 | |
dc.description.abstract | The pain assessment in advanced dementia (PAINAD) appears to be a clinically useful tool. However, the salivary determination of tumor necrosis factor receptor type II (sTNF-RII) and secretory IgA (sIgA) as pain biomarkers is still incipient. The aim was to correlate the PAINAD score with sTNF-RII and sIgA biomarker levels in the saliva of patients with advanced dementia. In this regard, a cross-sectional study was conducted. The sample consisted of 75 elderly patients with a clinical diagnosis of dementia and a global deterioration scale (GDS) score of 5 to 7. The PAINAD scale was determined by a previously trained professional and the collection of salivary samples was performed using the passive secretion method. Human sTNF-RII and sIgA using ELISA kits. The results showed a correlation between the PAINAD scale (numeric, binary, and recoded) and sTNF-RII and sIgA (p < 0.001). No association between the sociodemographic and clinical variables and the PAINAD scale was found (p > 0.05). Between 97.3% and 96.2% of patients with pain on the PAINAD scale also showed pain based on the sTNF-RII levels; in all of them, sIgA levels did not fit the logistic models. Therefore, the correlation highlights the usefulness of this scale and confirms the usefulness of sTNF-RII and sIgA as biomarkers of pain. | es_ES |
dc.description.sponsorship | This study was supported by the Junta de Andalucía through a regional health research fund (Research code: PI-0357-2017.) | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Biomarkers | es_ES |
dc.subject | Dementia | es_ES |
dc.subject | Nursing | es_ES |
dc.subject | Pain | es_ES |
dc.subject | Pain Assessment in Advanced Dementia (PAINAD) | es_ES |
dc.title | Correlation between biomarkers of pain in saliva and PAINAD Scale in elderly people with cognitive impairment and inability to communicate. | es_ES |
dc.type | research article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 33915996 | es_ES |
dc.format.volume | 10 | es_ES |
dc.format.number | 7 | es_ES |
dc.identifier.doi | 10.3390/jcm10071424 | es_ES |
dc.contributor.funder | Regional Government of Andalusia (España) | es_ES |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/jcm10071424 | es_ES |
dc.identifier.journal | Journal of Clinical Medicine | es_ES |
dc.repisalud.centro | ISCIII | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.rights.accessRights | open access | es_ES |