Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/12693
Título
Brain metastasis.
Autor(es)
Fecha de publicación
2020-01-20
Cita
Nat Rev Cancer.2020;20(1):4-11.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Brain metastasis, which commonly arises in patients with lung cancer, breast cancer and melanoma, is associated with poor survival outcomes and poses distinct clinical challenges. The brain microenvironment, with its unique cell types, anatomical structures, metabolic constraints and immune environment, differs drastically from microenvironments of extracranial lesions, imposing a distinct and profound selective pressure on tumour cells that, in turn, shapes the metastatic process and therapeutic responses. Accordingly, the study of brain metastasis could uncover new therapeutic targets and identify novel treatment approaches to address the unmet clinical need. Moreover, such efforts could provide insight into the biology of primary brain tumours, which face similar challenges to brain metastases of extracranial origin, and vice versa. However, the paucity of robust preclinical models of brain metastasis has severely limited such investigations, underscoring the importance of developing improved experimental models that holistically encompass the metastatic cascade and/or brain microenvironment. In this Viewpoint, we asked four leading experts to provide their opinions on these important aspects of brain metastasis biology and management.
MESH
Animals | Brain Neoplasms | Combined Modality Therapy | Disease Management | Disease Models, Animal | Disease Susceptibility | Humans | Quality Indicators, Health Care | Treatment Outcome | Tumor Microenvironment
Versión en línea
DOI
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