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dc.contributor.authorBoire, Adrienne
dc.contributor.authorBrastianos, Priscilla K
dc.contributor.authorGarzia, Livia
dc.contributor.authorValiente, Manuel
dc.identifier.citationNat Rev Cancer.2020;20(1):4-11.es_ES
dc.description.abstractBrain metastasis, which commonly arises in patients with lung cancer, breast cancer and melanoma, is associated with poor survival outcomes and poses distinct clinical challenges. The brain microenvironment, with its unique cell types, anatomical structures, metabolic constraints and immune environment, differs drastically from microenvironments of extracranial lesions, imposing a distinct and profound selective pressure on tumour cells that, in turn, shapes the metastatic process and therapeutic responses. Accordingly, the study of brain metastasis could uncover new therapeutic targets and identify novel treatment approaches to address the unmet clinical need. Moreover, such efforts could provide insight into the biology of primary brain tumours, which face similar challenges to brain metastases of extracranial origin, and vice versa. However, the paucity of robust preclinical models of brain metastasis has severely limited such investigations, underscoring the importance of developing improved experimental models that holistically encompass the metastatic cascade and/or brain microenvironment. In this Viewpoint, we asked four leading experts to provide their opinions on these important aspects of brain metastasis biology and management.es_ES
dc.description.sponsorshipM.V. acknowledges support from the Ministry of Economy and Competitiveness (MINECO) grant MINECO-Retos SAF2017-89643-R, the Bristol-Myers Squibb-Melanoma Research Alliance Young Investigator Award 2017 (498103), the Beug Foundation's Prize for Metastasis Research 2017, Fundacion Ramon Areces (CIVP19S8163), Worldwide Cancer Research (19-0177), Horizon 2020 Funding and Emerging Technologies (FET) Open (828972), the Clinic and Laboratory Integration Program Cancer Research Institute (CRI) Award 2018 (54545) and Spanish Association Against Cancer (AECC) Coordinated Translational Groups 2017 (GCTRA16015SEOA). M.V. is a Ramon y Cajal Investigator (RYC-2013-13365) and a member of the European Molecular Biology Organization Young Investigator Programme (EMBO YIP; 4053). L.G. is supported by CIHR Operating Grant PJT-162234, Terry Fox Research Institute grant TFRI1087, Canadian Cancer Society Research Institute CCS#705799, the Cancer Research Society and the C17 Research Network.es_ES
dc.publisherNature Publishing Groupes_ES
dc.subject.meshAnimals es_ES
dc.subject.meshBrain Neoplasms es_ES
dc.subject.meshCombined Modality Therapy es_ES
dc.subject.meshDisease Management es_ES
dc.subject.meshDisease Models, Animales_ES
dc.subject.meshDisease Susceptibility es_ES
dc.subject.meshHumans es_ES
dc.subject.meshQuality Indicators, Health Carees_ES
dc.subject.meshTreatment Outcome es_ES
dc.subject.meshTumor Microenvironment es_ES
dc.titleBrain metastasis.es_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.contributor.funderMinisterio de Economia y Competividad (MINECO)
dc.contributor.funderBristol-Myers Squibb-Melanoma Research Alliance Young Investigator Award 2017
dc.contributor.funderBeug Foundation
dc.contributor.funderFundacion Ramon Areces
dc.contributor.funderWorldwide Cancer Research
dc.contributor.funderHorizon 2020 Funding and Emerging Technologies (FET) Open
dc.contributor.funderClinic and Laboratory Integration Program Cancer Research Institute (CRI) Award 2018
dc.contributor.funderSpanish Association Against Cancer (AECC) Coordinated Translational Groups 2017
dc.contributor.funderEuropean Molecular Biology Organization Young Investigator Programme (EMBO YIP)
dc.contributor.funderCanadian Institutes of Health Research (CIHR)
dc.contributor.funderTerry Fox Research Institute Grant
dc.contributor.funderCanadian Cancer Society Research Institute CCS
dc.contributor.funderC17 Research Network
dc.identifier.journalNature reviews. Canceres_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Metástasis Cerebrales_ES

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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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