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dc.contributor.authorMarbán-Castro, Elena
dc.contributor.authorGoncé, Anna
dc.contributor.authorFumadó, Victoria
dc.contributor.authorMartínez, Miguel J
dc.contributor.authorLópez, Marta
dc.contributor.authorGarcía-Otero, Laura
dc.contributor.authorSalazar, Laura
dc.contributor.authorEsteve, Carolina
dc.contributor.authorSalvia, Dolors
dc.contributor.authorFortuny, Claudia
dc.contributor.authorEixarch, Elisenda
dc.contributor.authorFuente-Moreno, Marina
dc.contributor.authorPinazo, María Jesús
dc.contributor.authorOliveira, Inés
dc.contributor.authorRodríguez-Valero, Natalia
dc.contributor.authorRequena-Méndez, Ana
dc.contributor.authorCamprubí, Daniel
dc.contributor.authorSaco, Adela
dc.contributor.authorCastillo, Paola
dc.contributor.authorVazquez, Ana 
dc.contributor.authorDe Ory, Fernando de 
dc.contributor.authorNavero-Castillejos, Jessica
dc.contributor.authorCasellas, Aina
dc.contributor.authorGonzález, Raquel
dc.contributor.authorMuñoz, José
dc.contributor.authorGascón, Joaquim
dc.contributor.authorOrdi, Jaume
dc.contributor.authorMenéndez, Clara
dc.contributor.authorBardají, Azucena
dc.identifier.citationTravel Med Infect Dis . 2021 Feb 15;40:101985.es_ES
dc.description.abstractThe emergence of Zika virus (ZIKV) represents a threat with consequences on maternal and children's health. We aimed to assess the clinical and epidemiological characteristics of pregnant women returning from ZIKV affected areas, and the effects of maternal ZIKV infection on birth outcomes and children's health. This was a hospital-based prospective observational study conducted at the Hospital Clínic of Barcelona and Hospital Sant Joan de Déu, Barcelona, Spain, from January 2016 to February 2020. One hundred and ninety-five pregnant women who had travelled to ZIKV affected areas during pregnancy were recruited. Four women (2.1%) had a confirmed ZIKV infection, 40 women (20.5%) a probable infection, and 151 (77.4%) were negative for ZIKV. Among the ZIKV confirmed cases, a pregnant woman suffered a miscarriage, highly plausible to be associated with ZIKV infection. Brain cysts and microcalcifications were detected in 7% of fetuses or infants from women with confirmed or probable ZIKV infection. Neurodevelopmental delay in the language function was found in 33.3% out of the 21 children evaluated. These findings contribute to the understanding of ZIKV prevalence estimates, and the impact of maternal ZIKV infection on pregnancy outcomes and children's health. Results highlight the importance of long-term surveillance in pregnant travellers and their children.es_ES
dc.description.sponsorshipThis work was supported by the Government of Spain [grant number PI16/0123, ISCIII-AES Proyectos de Investigación en Salud, 2016]; a predoctoral fellowship from “la Caixa” Foundation (ID 100010434) [fellowship LCF/BQ/ES17/11600006]; the Ministry of Science, Innovation and Universities, Government of Spain through a Ramon y Cajal Grant [RYC-2013-14,512]; RICET, a Tropical Disease Cooperative Research Network in Spain [RD12/0018/0010] cofounded by ISCIII and the Fondo Europeo de Desarrollo Regional (FEDER); the Departament d’Universitats I Recerca de la Generalitat de Catalunya, Spain, AGAUR [grant 2017SGR924]; and ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya.es_ES
dc.publisherElsevier es_ES
dc.subjectZika viruses_ES
dc.titleZika virus infection in pregnant travellers and impact on childhood neurodevelopment in the first two years of life: A prospective observational study.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España) 
dc.contributor.funderRETICS-Investigación colaborativa en Enfermedades Tropicales (RICET-ISCIII) (España) 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderGovernment of Catalonia (España) 
dc.contributor.funderFundación La Caixa 
dc.identifier.journalTravel medicine and infectious diseasees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.rights.accessRightsopen accesses_ES

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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