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dc.contributor.authorBernal-Martinez, Leticia 
dc.contributor.authorGonçalves, S M
dc.contributor.authorAndres, Belen de 
dc.contributor.authorCunha, C
dc.contributor.authorGonzalez Jimenez, I
dc.contributor.authorLagrou, K
dc.contributor.authorMellado, Emilia 
dc.contributor.authorGaspar, Maria Luisa 
dc.contributor.authorMaertens, J A
dc.contributor.authorCarvalho, A
dc.contributor.authorAlcazar-Fuoli, Laura 
dc.date.accessioned2021-03-02T12:53:03Z
dc.date.available2021-03-02T12:53:03Z
dc.date.issued2021-12
dc.identifier.citationVirulence . 2021 Dec;12(1):570-583.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/12065
dc.description.abstractPattern recognition receptors (PRRs) are responsible for Aspergillus fumigatus recognition by innate immunity and its subsequent immune signaling. The triggering receptor expressed on myeloid cells 1 (TREM1) is a recently characterized pro-inflammatory receptor constitutively expressed on the surface of neutrophils and macrophages. A soluble form (sTREM1) of this protein that can be detected in human body fluids has been identified. Here we investigated the role of TREM1 during invasive pulmonary aspergillosis (IPA). IPA patients displayed significantly higher levels of sTREM1 in bronchoalveolar lavages when compared to control patients. Functional analysis in TREM1 showed that the levels of sTREM1 and TREM1 pathway-related cytokines were influenced by single nucleotide polymorphisms in TREM1. In addition, we confirmed a role of TREM1 on antifungal host defense against A. fumigatus in a murine model of IPA. TREM1 deficiency increased susceptibility to infection in the immunosuppressed murine host. Deletion of TREM1 showed delayed innate and adaptive immune responses and impaired pro-inflammatory cytokine responses. The absence of TREM1 in primary macrophages attenuated the TLR signaling by altering the expression of both receptor and effector proteins that are critical to the response against A. fumigatus. In this study, and for the first time, we demonstrate the key role for the TREM1 receptor pathway during IPA.es_ES
dc.description.sponsorshipThis work was supported by the Fundação para a Ciência e a Tecnologia [PTDC/SAU-SER/29635/2017]; Fundação para a Ciência e a Tecnologia [UIDB/50026/2020 and UIDP/50026/2020]; Fundação para a Ciência e a Tecnologia [PTDC/MED-GEN/28778/2017]; H2020 Excellent Science [NORTE-01-0145-FEDER-000013 and NORTE-01-0145-FEDER-000023)]; Instituto de Salud Carlos III [RD16/CIII/0004/0003]; Instituto de Salud Carlos III [PI18CIII/00045]; Instituto de Salud Carlos III [MPY 1277/15]; Ministerio de Ciencia, Innovación y Universidades [RTI2018-099114-B-I00]; Associação Viver a Ciência (PT) [SFRH/BD/136814/2018]; “la Caixa” Foundation [ID 100010434].es_ES
dc.language.isoenges_ES
dc.publisherTaylor & Francis es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectAspergillus fumigatuses_ES
dc.subjectTREM1es_ES
dc.subjectDiagnostic biomarkers and fungal immune responsees_ES
dc.titleTREM1 regulates antifungal immune responses in invasive pulmonary aspergillosis.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33525982
dc.format.volume12es_ES
dc.format.number1es_ES
dc.format.page570-583es_ES
dc.identifier.doi10.1080/21505594.2021.1879471es_ES
dc.contributor.funderUnión Europea. Comisión Europea. H2020 
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España) 
dc.contributor.funderFundación La Caixa 
dc.contributor.funderFundação para a Ciência e Tecnologia (Portugal) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn2150-5608es_ES
dc.relation.publisherversionhttps://doi.org/10.1080/21505594.2021.1879471es_ES
dc.identifier.journalVirulencees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/NORTE-01-0145-FEDER-000013es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/NORTE-01-0145-FEDER-000023es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16/CIII/0004/0003es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI18CIII/00045es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MPY 1277/15es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RTI2018-099114-B-I00es_ES
dc.rights.accessRightsopen accesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
This item is licensed under a: Attribution-NonCommercial-NoDerivatives 4.0 Internacional