Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/11913
Título
The global meningitis genome partnership
Autor(es)
Rodgers, Elizabeth | Bentley, Stephen D | Borrow, Ray | Bratcher, Holly B | Brisse, Sylvain | Brueggemann, Angela B | Caugant, Dominique A | Findlow, Jamie | Fox, LeAnne | Glennie, Linda | Harrison, Lee H | Harrison, Odile B | Heyderman, Robert S | van Rensburg, Melissa Jansen | Jolley, Keith A | Kwambana-Adams, Brenda | Ladhani, Shamez | LaForce, Marc | Levin, Michael | Lucidarme, Jay | MacAlasdair, Neil | Maclennan, Jenny | Maiden, Martin C J | Maynard-Smith, Laura | Muzzi, Alessandro | Oster, Philipp | Rodrigues, Charlene M C | Ronveaux, Olivier | Serino, Laura | Smith, Vinny | van der Ende, Arie | Vazquez-Moreno, Julio Alberto ISCIII | Wang, Xin | Yezli, Saber | Stuart, James M
Fecha de publicación
2020-10
Cita
J Infect . 2020 Oct;81(4):510-520.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Genomic surveillance of bacterial meningitis pathogens is essential for effective disease control globally, enabling identification of emerging and expanding strains and consequent public health interventions. While there has been a rise in the use of whole genome sequencing, this has been driven predominately by a subset of countries with adequate capacity and resources. Global capacity to participate in surveillance needs to be expanded, particularly in low and middle-income countries with high disease burdens. In light of this, the WHO-led collaboration, Defeating Meningitis by 2030 Global Roadmap, has called for the establishment of a Global Meningitis Genome Partnership that links resources for: N. meningitidis (Nm), S. pneumoniae (Sp), H. influenzae (Hi) and S. agalactiae (Sa) to improve worldwide co-ordination of strain identification and tracking. Existing platforms containing relevant genomes include: PubMLST: Nm (31,622), Sp (15,132), Hi (1935), Sa (9026); The Wellcome Sanger Institute: Nm (13,711), Sp (> 24,000), Sa (6200), Hi (1738); and BMGAP: Nm (8785), Hi (2030). A steering group is being established to coordinate the initiative and encourage high-quality data curation. Next steps include: developing guidelines on open-access sharing of genomic data; defining a core set of metadata; and facilitating development of user-friendly interfaces that represent publicly available data.
Palabras clave
Bacterial meningitis | Epidemiology | Genome partnership | Haemophilus influenzae | Neisseria meningitidis | Streptococcus agalactiae | Streptococcus pneumoniae | Whole genome sequencing
Versión en línea
DOI
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