Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/11913
The global meningitis genome partnership.
Rodgers, Elizabeth | Bentley, Stephen D | Borrow, Ray | Bratcher, Holly B | Brisse, Sylvain | Brueggemann, Angela B | Caugant, Dominique A | Findlow, Jamie | Fox, LeAnne | Glennie, Linda | Harrison, Lee H | Harrison, Odile B | Heyderman, Robert S | van Rensburg, Melissa Jansen | Jolley, Keith A | Kwambana-Adams, Brenda | Ladhani, Shamez | LaForce, Marc | Levin, Michael | Lucidarme, Jay | MacAlasdair, Neil | Maclennan, Jenny | Maiden, Martin C J | Maynard-Smith, Laura | Muzzi, Alessandro | Oster, Philipp | Rodrigues, Charlene M C | Ronveaux, Olivier | Serino, Laura | Smith, Vinny | van der Ende, Arie | Vazquez-Moreno, Julio Alberto ISCIII | Wang, Xin | Yezli, Saber | Stuart, James M
J Infect . 2020 Oct;81(4):510-520.
Genomic surveillance of bacterial meningitis pathogens is essential for effective disease control globally, enabling identification of emerging and expanding strains and consequent public health interventions. While there has been a rise in the use of whole genome sequencing, this has been driven predominately by a subset of countries with adequate capacity and resources. Global capacity to participate in surveillance needs to be expanded, particularly in low and middle-income countries with high disease burdens. In light of this, the WHO-led collaboration, Defeating Meningitis by 2030 Global Roadmap, has called for the establishment of a Global Meningitis Genome Partnership that links resources for: N. meningitidis (Nm), S. pneumoniae (Sp), H. influenzae (Hi) and S. agalactiae (Sa) to improve worldwide co-ordination of strain identification and tracking. Existing platforms containing relevant genomes include: PubMLST: Nm (31,622), Sp (15,132), Hi (1935), Sa (9026); The Wellcome Sanger Institute: Nm (13,711), Sp (> 24,000), Sa (6200), Hi (1738); and BMGAP: Nm (8785), Hi (2030). A steering group is being established to coordinate the initiative and encourage high-quality data curation. Next steps include: developing guidelines on open-access sharing of genomic data; defining a core set of metadata; and facilitating development of user-friendly interfaces that represent publicly available data.
Bacterial meningitis | Epidemiology | Genome partnership | Haemophilus influenzae | Neisseria meningitidis | Streptococcus agalactiae | Streptococcus pneumoniae | Whole genome sequencing
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