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dc.contributor.authorGutierrez-Gonzalez, Enrique 
dc.contributor.authorCantero-Escribano, José M
dc.contributor.authorRedondo Bravo, Lidia
dc.contributor.authorSan Juan-Sanz, Isabel
dc.contributor.authorRobustillo-Rodela, Ana
dc.contributor.authorCendejas-Bueno, Emilio
dc.contributor.authorInfluenza Working Group
dc.date.accessioned2021-02-16T13:56:31Z
dc.date.available2021-02-16T13:56:31Z
dc.date.issued2019
dc.identifier.citationJ Infect Public Health. Jul-Aug 2019;12(4):486-491.es_ES
dc.identifier.issn1876-0341es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11911
dc.description.abstractIdentifying risk factors for complications or death associated with influenza remains crucial to target preventive interventions. Scores like the Charlson comorbidity index (CCI) may be of help. The aims of this study were to assess the effect of vaccination and comorbidities on severe influenza disease and influenza-related death among hospitalized patients during the season 2016/17; and to evaluate the validity of the CCI to predict death among these patients. Data from adult patients (≥18 years old) with influenza infection admitted to La Paz University Hospital (LPUH) were recorded during the 2016/17 epidemic. The effect of influenza vaccine to prevent severe influenza or death was evaluated using multivariate logistic regression models. The area under the curve of the CCI and the age-adjusted CCI were compared to assess the predictive effect on mortality. A total of 342 adult patients with influenza infection were admitted, of which 83 developed severe influenza and 25 died during hospitalization. There were no differences between patients who survived and those who died concerning the CCI, but the age-adjusted CCI was higher in fatal cases (p-value=0.005). Influenza vaccine had no statistically significant effect on the risk of mortality (p-value=0.162) while age (OR: 1.12, p-value<0.001) and dementia (OR: 3.05, p-value=0.016) proved to be independent predictors for mortality. The seasonal vaccine was found to be protective for severe infection (OR: 0.54, p-value=0.019). The age-adjusted CCI was a better predictor of mortality than the crude CCI. Age and dementia are significant independent risk factors for mortality associated with influenza among hospitalized patients. The age-adjusted CCI seems to be a better predictor of mortality than the crude CCI. Influenza vaccine has shown to be effective in preventing severe influenza in the season 2016/17 among hospitalized patients and should be promoted in population at risk.es_ES
dc.language.isoenges_ES
dc.publisherElsevier es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectComorbidityes_ES
dc.subjectInfluenza vaccinees_ES
dc.subjectInfluenza viruses_ES
dc.subjectMortalityes_ES
dc.subjectSevere influenzaes_ES
dc.subject.meshAge Factors es_ES
dc.subject.meshAged es_ES
dc.subject.meshAged, 80 and over es_ES
dc.subject.meshComorbidity es_ES
dc.subject.meshEpidemics es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHospitalization es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInfluenza Vaccines es_ES
dc.subject.meshInfluenza, Human es_ES
dc.subject.meshLogistic Models es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshPrognosis es_ES
dc.subject.meshRisk Assessment es_ES
dc.subject.meshRisk Factors es_ES
dc.subject.meshSeverity of Illness Index es_ES
dc.subject.meshSpain es_ES
dc.subject.meshTertiary Care Centers es_ES
dc.subject.meshVaccination es_ES
dc.titleEffect of vaccination, comorbidities and age on mortality and severe disease associated with influenza during the season 2016-2017 in a Spanish tertiary hospital.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.identifier.pubmedID30670352es_ES
dc.format.volume12es_ES
dc.format.number4es_ES
dc.format.page486-491es_ES
dc.identifier.doi10.1016/j.jiph.2018.11.011es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1876-035Xes_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.jiph.2018.11.011es_ES
dc.identifier.journalJournal of infection and public healthes_ES
dc.repisalud.centroISCIII::Escuela Nacional de Sanidades_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES


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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 Internacional