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dc.contributor.authorFernández, André Renaldo
dc.contributor.authorSánchez-Tarjuelo, Rodrigo 
dc.contributor.authorCravedi, Paolo
dc.contributor.authorCano-Ochando, Jordi 
dc.contributor.authorLópez-Hoyos, Marcos
dc.date.accessioned2021-02-03T11:47:06Z
dc.date.available2021-02-03T11:47:06Z
dc.date.issued2020-11-13
dc.identifier.citationInt J Mol Sci . 2020 Nov 13;21(22):8549.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11787
dc.description.abstractThanks to the development of new, more potent and selective immunosuppressive drugs together with advances in surgical techniques, organ transplantation has emerged from an experimental surgery over fifty years ago to being the treatment of choice for many end-stage organ diseases, with over 139,000 organ transplants performed worldwide in 2019. Inherent to the transplantation procedure is the fact that the donor organ is subjected to blood flow cessation and ischemia during harvesting, which is followed by preservation and reperfusion of the organ once transplanted into the recipient. Consequently, ischemia/reperfusion induces a significant injury to the graft with activation of the immune response in the recipient and deleterious effect on the graft. The purpose of this review is to discuss and shed new light on the pathways involved in ischemia/reperfusion injury (IRI) that act at different stages during the donation process, surgery, and immediate post-transplant period. Here, we present strategies that combine various treatments targeted at different mechanistic pathways during several time points to prevent graft loss secondary to the inflammation caused by IRI.es_ES
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectRNA interferencees_ES
dc.subjectCell deathes_ES
dc.subjectCell metabolismes_ES
dc.subjectHypoxiaes_ES
dc.subjectInnate immunityes_ES
dc.subjectIschemia reperfusion injuryes_ES
dc.titleReview: Ischemia Reperfusion Injury-A Translational Perspective in Organ Transplantation.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33202744es_ES
dc.format.volume21es_ES
dc.format.number22es_ES
dc.identifier.doi10.3390/ijms21228549es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1422-0067es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/ijms21228549es_ES
dc.identifier.journalInternational journal of molecular scienceses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución 4.0 Internacional
This item is licensed under a: Atribución 4.0 Internacional