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dc.contributor.author | Hurtado, A | |
dc.contributor.author | Alonso, E | |
dc.contributor.author | Aspiritxaga, I | |
dc.contributor.author | López Etxaniz, I | |
dc.contributor.author | Ocabo, B | |
dc.contributor.author | Barandika, Jesús Félix | |
dc.contributor.author | Fernández-Ortiz DE Murúa, J I | |
dc.contributor.author | Urbaneja, F | |
dc.contributor.author | Álvarez-Alonso, R | |
dc.contributor.author | Jado, Isabel | |
dc.contributor.author | García-Pérez, A L | |
dc.date.accessioned | 2021-02-03T07:28:43Z | |
dc.date.available | 2021-02-03T07:28:43Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Epidemiol Infect . 2017 Jul;145(9):1834-1842. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/11783 | |
dc.description.abstract | A Q fever outbreak was declared in February 2016 in a company that manufactures hoists and chains and therefore with no apparent occupational-associated risk. Coxiella burnetii infection was diagnosed by serology in eight of the 29 workers of the company; seven of them had fever or flu-like signs and five had pneumonia, one requiring hospitalisation. A further case of C. burnetii pneumonia was diagnosed in a local resident. Real-time PCR (RTi-PCR) showed a widespread distribution of C. burnetii DNA in dust samples collected from the plant facilities, thus confirming the exposure of workers to the infection inside the factory. Epidemiological investigations identified a goat flock with high C. burnetii seroprevalence and active shedding which was owned and managed by one of the workers of the company as possible source of infection. Genotyping by multispacer sequence typing (MST) and a 10-loci single-nucleotide polymorphism (SNP) discrimination using RTi-PCR identified the same genotype (MST18 and SNP type 8, respectively) in the farm and the factory. These results confirmed the link between the goat farm and the outbreak and allowed the identification of the source of infection. The circumstances and possible vehicles for the bacteria entering the factory are discussed. | es_ES |
dc.description.sponsorship | This study was supported by the Spanish National Institute for Agricultural and Food Research and Technology (INIA RTA 2013-00051-C2-00) and the European Regional Development Fund (ERDF). RAA is the recipient of a predoctoral fellowship from INIA. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Cambridge University Press | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Coxiella burnetii | es_ES |
dc.subject | Q fever | es_ES |
dc.subject | Dust | es_ES |
dc.subject | Genotyping | es_ES |
dc.subject | Outbreak | es_ES |
dc.subject.mesh | Disease Outbreaks | es_ES |
dc.subject.mesh | Environmental Microbiology | es_ES |
dc.subject.mesh | Genotype | es_ES |
dc.subject.mesh | Real-Time Polymerase Chain Reaction | es_ES |
dc.subject.mesh | Adolescent | es_ES |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Animals | es_ES |
dc.subject.mesh | Coxiella burnetii | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | Genotyping Techniques | es_ES |
dc.subject.mesh | Goat Diseases | es_ES |
dc.subject.mesh | Goats | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Occupational Diseases | es_ES |
dc.subject.mesh | Prevalence | es_ES |
dc.subject.mesh | Q Fever | es_ES |
dc.subject.mesh | Seroepidemiologic Studies | es_ES |
dc.subject.mesh | Spain | es_ES |
dc.title | Environmental sampling coupled with real-time PCR and genotyping to investigate the source of a Q fever outbreak in a work setting. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 28434420 | es_ES |
dc.format.volume | 145 | es_ES |
dc.format.number | 9 | es_ES |
dc.format.page | 1834-1842 | es_ES |
dc.identifier.doi | 10.1017/S0950268817000796 | es_ES |
dc.contributor.funder | Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (España) | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1469-4409 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1017/S0950268817000796 | es_ES |
dc.identifier.journal | Epidemiology and infection | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/INIA RTA 2013-00051-C2-00 | es_ES |
dc.rights.accessRights | open access | es_ES |