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Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000-2015.

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URI: http://hdl.handle.net/20.500.12105/11643
DOI: 10.3201/eid2701.190782
Publication date
2021-01
Authors
Pérez-Nadales, Elena
Linares-Sicilia, María José
Soto-Debran, Juan Carlos
Abdala, Edson
García-Rodríguez, Julio
Montejo, Miguel
Muñoz, Patricia
Lletí, Miguel Salavert
Rezusta, Antonio
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Centers for Disease Control and Prevention (CDC)
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Abstract
Invasive fusariosis (IF) is associated with severe neutropenia in patients with concurrent hematologic conditions. We conducted a retrospective observational study to characterize the epidemiology of IF in 18 Spanish hospitals during 2000-2015. In that time, the frequency of IF in nonneutropenic patients increased from 0.08 cases per 100,000 admissions in 2000-2009 to 0.22 cases per 100,000 admissions in 2010-2015. Nonneutropenic IF patients often had nonhematologic conditions, such as chronic cardiac or lung disease, rheumatoid arthritis, history of solid organ transplantation, or localized fusariosis. The 90-day death rate among nonneutropenic patients (28.6%) and patients with resolved neutropenia (38.1%) was similar. However, the death rate among patients with persistent neutropenia (91.3%) was significantly higher. We used a multivariate Cox regression analysis to characterize risk factors for death: persistent neutropenia was the only risk factor for death, regardless of antifungal therapy.
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Emerg Infect Dis . 2021 Jan;27(1):26-35
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Centro Nacional de Microbiología (CNM)
i+12 - Instituto de Investigación Hospital 12 de Octubre (Madrid)
IDIVAL - Instituto de Investigación Marqués de Valdecilla (Cantabria)
IIS Aragón - Instituto de Investigación Sanitaria Aragón (Aragón)
IiSGM - Instituto de Investigación Sanitaria Gregorio Marañón (Madrid)
IMIBIC - Instituto Maimónides de Investigación Biomédica de Córdoba (Andalucía)
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https://doi.org/10.3201/eid2701.190782
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research article