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dc.contributor.authorOrdikhani, Farideh
dc.contributor.authorPothula, Venu
dc.contributor.authorSanchez-Tarjuelo, Rodrigo
dc.contributor.authorJordan, Stefan
dc.contributor.authorCano-Ochando, Jordi 
dc.date.accessioned2021-01-19T09:46:31Z
dc.date.available2021-01-19T09:46:31Z
dc.date.issued2020
dc.identifier.citationFront Immunol . 2020 Nov 30;11:582939.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11638
dc.description.abstractCurrent immunosuppressive therapy has led to excellent short-term survival rates in organ transplantation. However, long-term graft survival rates are suboptimal, and a vast number of allografts are gradually lost in the clinic. An increasing number of animal and clinical studies have demonstrated that monocytes and macrophages play a pivotal role in graft rejection, as these mononuclear phagocytic cells recognize alloantigens and trigger an inflammatory cascade that activate the adaptive immune response. Moreover, recent studies suggest that monocytes acquire a feature of memory recall response that is associated with a potent immune response. This form of memory is called "trained immunity," and it is retained by mechanisms of epigenetic and metabolic changes in innate immune cells after exposure to particular ligands, which have a direct impact in allograft rejection. In this review article, we highlight the role of monocytes and macrophages in organ transplantation and summarize therapeutic approaches to promote tolerance through manipulation of monocytes and macrophages. These strategies may open new therapeutic opportunities to increase long-term transplant survival rates in the clinic.es_ES
dc.description.sponsorshipThe authors’ work is supported by National Institutes of Health grants R01 AI139623AI (JO), and NIH-T32CA078207 (FO).es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Mediaes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectimmune tolerancees_ES
dc.subjectmacrophageses_ES
dc.subjectnanotherapyes_ES
dc.subjectorgan transplantationes_ES
dc.subjecttrained immunityes_ES
dc.titleMacrophages in Organ Transplantation.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33329555es_ES
dc.format.volume11es_ES
dc.format.page582939es_ES
dc.identifier.doi10.3389/fimmu.2020.582939es_ES
dc.contributor.funderNational Institutes of Health (United States)
dc.description.peerreviewedes_ES
dc.identifier.e-issn1664-3224
dc.relation.publisherversionhttps://doi.org/10.3389/fimmu.2020.582939es_ES
dc.identifier.journalFrontiers in immunologyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución 4.0 Internacional
This item is licensed under a: Atribución 4.0 Internacional