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dc.contributor.authorRoth, Gregory A
dc.contributor.authorMensah, George A
dc.contributor.authorJohnson, Catherine Owens
dc.contributor.authorAddolorato, Giovanni
dc.contributor.authorAmmirati, Enrico
dc.contributor.authorBaddour, Larry M
dc.contributor.authorBarengo, Noël C
dc.contributor.authorBeaton, Andrea Z
dc.contributor.authorBenjamin, Emelia J
dc.contributor.authorBenziger, Catherine P
dc.contributor.authorBonny, Aimé
dc.contributor.authorBrauer, Michael
dc.contributor.authorBrodmann, Marianne
dc.contributor.authorCahill, Thomas J
dc.contributor.authorCarapetis, Jonathan
dc.contributor.authorCatapano, Alberico
dc.contributor.authorChugh, Sumeet S
dc.contributor.authorCooper, Leslie T
dc.contributor.authorCoresh, Josef
dc.contributor.authorCriqui, Michael
dc.contributor.authorDeCleene, Nicole
dc.contributor.authorEagle, Kim A
dc.contributor.authorEmmons-Bell, Sophia
dc.contributor.authorFeigin, Valery L
dc.contributor.authorFernandez-Sola, Joaquim
dc.contributor.authorFowkes, Gerry
dc.contributor.authorGakidou, Emmanuela
dc.contributor.authorGrundy, Scott M
dc.contributor.authorHe, Feng J
dc.contributor.authorHoward, George
dc.contributor.authorHu, Frank
dc.contributor.authorInker, Lesley
dc.contributor.authorKarthikeyan, Ganesan
dc.contributor.authorKassebaum, Nicholas
dc.contributor.authorKoroshetz, Walter
dc.contributor.authorLavie, Carl
dc.contributor.authorLloyd-Jones, Donald
dc.contributor.authorLu, Hong S
dc.contributor.authorMirijello, Antonio
dc.contributor.authorTemesgen, Awoke Misganaw
dc.contributor.authorMokdad, Ali H
dc.contributor.authorMoran, Andrew E
dc.contributor.authorMuntner, Paul
dc.contributor.authorNarula, Jagat
dc.contributor.authorNeal, Bruce
dc.contributor.authorNtsekhe, Mpiko
dc.contributor.authorMoraes de Oliveira, Glaucia
dc.contributor.authorOtto, Catherine
dc.contributor.authorOwolabi, Mayowa Ojo
dc.contributor.authorPratt, Michael
dc.contributor.authorRajagopalan, Sanjay
dc.contributor.authorReitsma, Marissa
dc.contributor.authorRibeiro, Antonio Luiz P
dc.contributor.authorRigotti, Nancy
dc.contributor.authorRodgers, Anthony
dc.contributor.authorSable, Craig
dc.contributor.authorShakil, Saate
dc.contributor.authorSliwa-Hahnle, Karen
dc.contributor.authorStark, Benjamin
dc.contributor.authorSundström, Johan
dc.contributor.authorTimpel, Patrick
dc.contributor.authorTleyjeh, Imad M
dc.contributor.authorValgimigli, Marco
dc.contributor.authorVos, Theo
dc.contributor.authorWhelton, Paul K
dc.contributor.authorYacoub, Magdi
dc.contributor.authorZuhlke, Liesl
dc.contributor.authorMurray, Christopher J L
dc.contributor.authorFuster, Valentin 
dc.contributor.authorGBD-NHLBI-JACC Global Burden of Cardiovascular Diseases Writing Group
dc.contributor.authorCatalá-López, Ferrán 
dc.date.accessioned2021-01-08T10:29:43Z
dc.date.available2021-01-08T10:29:43Z
dc.date.issued2020-12-22
dc.identifier.citationJ Am Coll Cardiol. 2020; 76(25):2982-3021es_ES
dc.identifier.issn0735-1097
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11588
dc.descriptionPublished Erratum J Am Coll Cardiol. 2021 Apr 20;77(15):1958-1959. doi: 10.1016/j.jacc.2021.02.039. PMID: 33858636
dc.description.abstractCardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019. Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside high-income countries, and alarmingly, the age-standardized rate of CVD has begun to rise in some locations where it was previously declining in high-income countries. There is an urgent need to focus on implementing existing cost-effective policies and interventions if the world is to meet the targets for Sustainable Development Goal 3 and achieve a 30% reduction in premature mortality due to noncommunicable diseases.es_ES
dc.description.sponsorshipThis study was funded by the Bill and Melinda Gates Foundation. Dr. Benjamin has received funding from the National Institutes of Health (NIH)/National Heart, Lung, and Blood Institute (NHLBI) (R01HL092577, 1R01HL128914) and American Heart Association (18SFRN34110082). Dr. Brauer has received a grant from the Bill and Melinda Gates Foundation. Dr. Catapano has received support from Fondazione Cariplo 2015-0524 and 2015-0564, H2020 REPROGRAM PHC-03-2015/667837-2, ERA NET ER-2017-2364981, GR-2011- 02346974, Ministry of Health - Ricerca Corrente Multimedica; has received research grant/support from Sanofi, Sanofi Regeneron, Amgen, Mylan, Menarini, and Eli Lilly; has served on the speakers bureau for Akcea, Amgen, Sanofi, Esperion, Kowa, Novartis, Ionis Pharmaceuticals, Mylan, Menarini, Merck, Recordati, Regeneron, Daiichi-Sankyo, AstraZeneca, Aegerion, Amryt, and Sandoz; has received honoraria from Akcea, Amgen, Sanofi, Esperion, Kowa, Novartis, Ionis Pharmaceuticals, Mylan, Menarini, Merck, Recordati, Regeneron Daiichi-Sankyo, AstraZeneca, Aegerion, Amryt, and Sandoz; and has served as a consultant/on the Advisory Board for Akcea, Amgen, Sanofi, Esperion, Kowa, Novartis, Ionis Pharmaceuticals, Mylan, Menarini, Merck, Recordati, Regeneron Daiichi-Sankyo, Genzyme, Aegerion, and Sandoz. Dr. Coresh has received funding from the NIH and National Kidney Foundation; and has served as an advisor to Healthy.io. Dr. Fowkes has served on the Advisory Board for AstraZeneca. Dr. Muntner has received grants and personal fees from Amgen Inc. Dr. Ribeiro has received partial support by CNPq (310679/2016-8 and 465518/2014-1) and by FAPEMIG (PPM-00428-17). Dr. Zuhlke has received funding by the UK Medical Research Council (MRC) and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement and the National Research Foundation of South Africa. Dr. Rigotti has served as a consultant to Achieve Life Sciences; and has received royalties from UpToDate, Inc. Dr. Rodgers is employed by The George Institute for Global Health (TGI) and seconded part time to George Medicines Pty Ltd (GM); TGI has submitted patent applications with respect to low-fixed-dose combination products for the treatment of cardiovascular or cardiometabolic disease and is listed as one of the inventors; George Health Enterprises Pty. Ltd. (GHE) and its subsidiary, GM, have received investment funds to develop fixed-dose combination products, including combinations of blood pressure-lowering drugs; GHE is the social enterprise arm of TGI (Dr. Rodgers does not have a direct financial interest in these patent applications or investments). Dr. Sundström holds ownership in companies providing services to Itrim, Amgen, Janssen, Novo Nordisk, Eli Lilly, Boehringer Ingelheim, Bayer, Pfizer, and AstraZeneca, outside the submitted work. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.es_ES
dc.language.isoenges_ES
dc.publisherElsevier es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleGlobal Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33309175es_ES
dc.format.volume76es_ES
dc.format.number25es_ES
dc.format.page2982-3021es_ES
dc.identifier.doi10.1016/j.jacc.2020.11.010es_ES
dc.contributor.funderAegerion Pharmaceuticals (Estados Unidos) 
dc.contributor.funderAkcea Therapeutics 
dc.contributor.funderAmerican Heart Association 
dc.contributor.funderAmgen 
dc.contributor.funderAmryt Pharma 
dc.contributor.funderAstraZeneca 
dc.contributor.funderBill & Melinda Gates Foundation 
dc.contributor.funderNational Council for Scientific and Technological Development (Brasil) 
dc.contributor.funderDaiichi Sankyo 
dc.contributor.funderEli Lilly 
dc.contributor.funderUnión Europea. Comisión Europea. H2020. ERA-NET 
dc.contributor.funderEsperion Therapeutics (Estados Unidos) 
dc.contributor.funderFundação de Amparo à Pesquisa do Estado de São Paulo Minas Gerais (Brasil) 
dc.contributor.funderFondazione Cariplo 
dc.contributor.funderGeorge Medicines Pty Ltd (GM)
dc.contributor.funderUnión Europea. Comisión Europea. H2020 
dc.contributor.funderIonis Pharmaceuticals 
dc.contributor.funderKowa (Japón) 
dc.contributor.funderGrupo Menarini 
dc.contributor.funderMerck KGaA 
dc.contributor.funderMinistry of Health - Ricerca Corrente Multimedica
dc.contributor.funderMylan
dc.contributor.funderNIH - National Heart, Lung, and Blood Institute (NHLBI) (Estados Unidos) 
dc.contributor.funderNational Kidney Foundation (Estados Unidos) 
dc.contributor.funderNational Institutes of Health (Estados Unidos) 
dc.contributor.funderNovartis 
dc.contributor.funderRecordati 
dc.contributor.funderRegeneron (Estados Unidos) 
dc.contributor.funderSandoz Farmacéutica 
dc.contributor.funderSanofi 
dc.contributor.funderGeorge Institute for Global Health 
dc.contributor.funderDepartment for International Development (Reino Unido) 
dc.contributor.funderMedical Research Council (Reino Unido) 
dc.contributor.funderUpToDate, Inc.
dc.description.peerreviewedes_ES
dc.identifier.e-issn1558-3597es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.jacc.2020.11.010es_ES
dc.identifier.journalJournal of the American College of Cardiologyes_ES
dc.repisalud.centroISCIII::Escuela Nacional de Sanidad
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES
dc.repisalud.institucionCNICes_ES
dc.repisalud.institucionISCIII
dc.relation.projectIDnfo:eu-repo/grantAgreement/EC/H2020/PHC-03-2015/667837-2es_ES
dc.relation.projectIDnfo:eu-repo/grantAgreement/EC/H2020/ER-2017-2364981es_ES
dc.rights.accessRightsopen accesses_ES


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