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dc.contributor.authorTrickey, Adam
dc.contributor.authorvan Sighem, Ard
dc.contributor.authorStover, John
dc.contributor.authorAbgrall, Sophie
dc.contributor.authorGrabar, Sophie
dc.contributor.authorBonnet, Fabrice
dc.contributor.authorBerenguer, Juan
dc.contributor.authorWyen, Christoph
dc.contributor.authorCasabona, Jordi
dc.contributor.authord'Arminio Monforte, Antonella
dc.contributor.authorCavassini, Matthias
dc.contributor.authorAmo, Julia del 
dc.contributor.authorZangerle, Robert
dc.contributor.authorGill, M John
dc.contributor.authorObel, Niels
dc.contributor.authorSterne, Jonathan A C
dc.contributor.authorMay, Margaret T
dc.date.accessioned2020-11-30T10:15:28Z
dc.date.available2020-11-30T10:15:28Z
dc.date.issued2019
dc.identifier.citationAIDS . 2019 Dec 15;33 Suppl 3(Suppl 3):S271-S281.es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11471
dc.description.abstractHIV cohort data from high-income European countries were compared with the UNAIDS Spectrum modelling parameters for these same countries to validate mortality rates and excess mortality estimates for people living with HIV (PLHIV) on antiretroviral therapy (ART). Data from 2000 to 2015 were analysed from the Antiretroviral Therapy Cohort Collaboration (ART-CC) for Austria, Denmark, France, Italy, the Netherlands, Spain, and Switzerland. Flexible parametric models were used to compare all-cause mortality rates in the ART-CC and Spectrum. The percentage of AIDS-related deaths and excess mortality (both are the same within Spectrum) were compared, with excess mortality defined as that in excess of the general population mortality. Analyses included 94 026 PLHIV with 585 784 person-years of follow-up, from which there were 5515 deaths. All-cause annual mortality rates in Spectrum for 2000-2003 were 0.0121, reducing to 0.0078 in 2012-2015, whilst the ART-CC's corresponding annual mortality rates were 0.0151 [95% confidence interval (95% CI): 0.0130-0.0171] reducing to 0.0049 (95% CI: 0.0039-0.0060). The percentage of AIDS-related deaths in Spectrum was 74.7% in 2000-2003, dropping to 43.6% in 2012-2015. In the ART-CC, AIDS-related mortality constitutes 45.3% (95% CI: 38.4-52.9%) of mortality in 2000-2003 and 26.7% (95% CI: 19-46%) between 2012 and 2015. Excess mortality in the ART-CC was broadly similar to the Spectrum estimates, dropping from 75.3% (95% CI: 60.3-95.2%) in 2000-2003 to 30.7% (95% CI: 25.5-63.7%) in 2012-2015. All-cause mortality assumptions for PLHIV on ART in high-income European settings should be adjusted in Spectrum to be higher in 2000-2003 and decline more quickly to levels currently captured for recent years.es_ES
dc.description.sponsorshipFunding: This work was supported by the UK Medical Research Council (MRC; grant number MR/J002380/1) and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement and is also part of the EDCTP2 programme supported by the European Union. The ART-CC is funded by the US National Institute on Alcohol Abuse and Alcoholism (U01-AA026209). J.A.C.S. is funded by National Institute for Health Research Senior Investigator award NF-SI-0611-10168. Data from 11 European cohorts were pooled within COHERE in EuroCoord. COHERE receives funding from the European Union Seventh Framework Programme (FP7/2007–2013) under EuroCoord grant agreement number 260694. Sources of funding of individual cohorts include the Agence Nationale de Recherche sur le SIDA et les hépatites virales (ANRS), the Institut National de la Santé et de la Recherche Médicale (INSERM), the French, Italian, and Spanish Ministries of Health, the Swiss National Science Foundation (grant 33CS30_134277), the Ministry of Science and Innovation and the Spanish Network for AIDS Research (RIS; ISCIII-RETIC RD06/006), the Stichting HIV Monitoring, the European Commission (EuroCoord grant 260694), and unrestricted grants from Abbott, Gilead, Tibotec-Upjohn, ViiV Healthcare, MSD, GlaxoSmithKline, Pfizer, Bristol-Myers Squibb, Roche, and Boehringer Ingelheim. The Danish HIV Cohort Study is funded by the Preben and Anne Simonsens Foundation.es_ES
dc.language.isoenges_ES
dc.publisherLippincott Williams & Wilkins (LWW) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshDeveloped Countries es_ES
dc.subject.meshAdult es_ES
dc.subject.meshAnti-HIV Agents es_ES
dc.subject.meshCohort Studies es_ES
dc.subject.meshEurope es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHIV Infections es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshModels, Statistical es_ES
dc.subject.meshMortality es_ES
dc.subject.meshRisk Factors es_ES
dc.titleParameter estimates for trends and patterns of excess mortality among persons on antiretroviral therapy in high-income European settings.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID31800404es_ES
dc.format.volume33 Suppl 3es_ES
dc.format.pageS271-S281es_ES
dc.identifier.doi10.1097/QAD.0000000000002387es_ES
dc.contributor.funderMedical Research Council (Reino Unido) 
dc.contributor.funderDepartment for International Development (Reino Unido) 
dc.contributor.funderNIH - National Institute on Alcohol Abuse and Alcoholism (NIAAA) (Estados Unidos) 
dc.contributor.funderNational Institute for Health Research (Reino Unido) 
dc.contributor.funderUnión Europea 
dc.contributor.funderAgence Nationale de Recherches sur le sida et les hépatites virales (Francia) 
dc.contributor.funderInstitut National de la Santé et de la Recherche Médicale (Francia) 
dc.contributor.funderMinistero della Salute (Italia) 
dc.contributor.funderMinisterio de Sanidad y Consumo (España) 
dc.contributor.funderMinisterio de Ciencia e Innovación (España) 
dc.contributor.funderRed de Investigación Cooperativa en Investigación en Sida (España) 
dc.contributor.funderSwiss National Science Foundation 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1473-5571
dc.relation.publisherversionhttp://dx.doi.org/10.1097/QAD.0000000000002387es_ES
dc.identifier.journalAIDS (London, England)es_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/260694es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RETIC/RD06/006es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
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