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dc.contributor.author | Trickey, Adam | |
dc.contributor.author | van Sighem, Ard | |
dc.contributor.author | Stover, John | |
dc.contributor.author | Abgrall, Sophie | |
dc.contributor.author | Grabar, Sophie | |
dc.contributor.author | Bonnet, Fabrice | |
dc.contributor.author | Berenguer, Juan | |
dc.contributor.author | Wyen, Christoph | |
dc.contributor.author | Casabona, Jordi | |
dc.contributor.author | d'Arminio Monforte, Antonella | |
dc.contributor.author | Cavassini, Matthias | |
dc.contributor.author | Amo, Julia del | |
dc.contributor.author | Zangerle, Robert | |
dc.contributor.author | Gill, M John | |
dc.contributor.author | Obel, Niels | |
dc.contributor.author | Sterne, Jonathan A C | |
dc.contributor.author | May, Margaret T | |
dc.date.accessioned | 2020-11-30T10:15:28Z | |
dc.date.available | 2020-11-30T10:15:28Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | AIDS . 2019 Dec 15;33 Suppl 3(Suppl 3):S271-S281. | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/11471 | |
dc.description.abstract | HIV cohort data from high-income European countries were compared with the UNAIDS Spectrum modelling parameters for these same countries to validate mortality rates and excess mortality estimates for people living with HIV (PLHIV) on antiretroviral therapy (ART). Data from 2000 to 2015 were analysed from the Antiretroviral Therapy Cohort Collaboration (ART-CC) for Austria, Denmark, France, Italy, the Netherlands, Spain, and Switzerland. Flexible parametric models were used to compare all-cause mortality rates in the ART-CC and Spectrum. The percentage of AIDS-related deaths and excess mortality (both are the same within Spectrum) were compared, with excess mortality defined as that in excess of the general population mortality. Analyses included 94 026 PLHIV with 585 784 person-years of follow-up, from which there were 5515 deaths. All-cause annual mortality rates in Spectrum for 2000-2003 were 0.0121, reducing to 0.0078 in 2012-2015, whilst the ART-CC's corresponding annual mortality rates were 0.0151 [95% confidence interval (95% CI): 0.0130-0.0171] reducing to 0.0049 (95% CI: 0.0039-0.0060). The percentage of AIDS-related deaths in Spectrum was 74.7% in 2000-2003, dropping to 43.6% in 2012-2015. In the ART-CC, AIDS-related mortality constitutes 45.3% (95% CI: 38.4-52.9%) of mortality in 2000-2003 and 26.7% (95% CI: 19-46%) between 2012 and 2015. Excess mortality in the ART-CC was broadly similar to the Spectrum estimates, dropping from 75.3% (95% CI: 60.3-95.2%) in 2000-2003 to 30.7% (95% CI: 25.5-63.7%) in 2012-2015. All-cause mortality assumptions for PLHIV on ART in high-income European settings should be adjusted in Spectrum to be higher in 2000-2003 and decline more quickly to levels currently captured for recent years. | es_ES |
dc.description.sponsorship | Funding: This work was supported by the UK Medical Research Council (MRC; grant number MR/J002380/1) and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement and is also part of the EDCTP2 programme supported by the European Union. The ART-CC is funded by the US National Institute on Alcohol Abuse and Alcoholism (U01-AA026209). J.A.C.S. is funded by National Institute for Health Research Senior Investigator award NF-SI-0611-10168. Data from 11 European cohorts were pooled within COHERE in EuroCoord. COHERE receives funding from the European Union Seventh Framework Programme (FP7/2007–2013) under EuroCoord grant agreement number 260694. Sources of funding of individual cohorts include the Agence Nationale de Recherche sur le SIDA et les hépatites virales (ANRS), the Institut National de la Santé et de la Recherche Médicale (INSERM), the French, Italian, and Spanish Ministries of Health, the Swiss National Science Foundation (grant 33CS30_134277), the Ministry of Science and Innovation and the Spanish Network for AIDS Research (RIS; ISCIII-RETIC RD06/006), the Stichting HIV Monitoring, the European Commission (EuroCoord grant 260694), and unrestricted grants from Abbott, Gilead, Tibotec-Upjohn, ViiV Healthcare, MSD, GlaxoSmithKline, Pfizer, Bristol-Myers Squibb, Roche, and Boehringer Ingelheim. The Danish HIV Cohort Study is funded by the Preben and Anne Simonsens Foundation. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Lippincott Williams & Wilkins (LWW) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Developed Countries | es_ES |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Anti-HIV Agents | es_ES |
dc.subject.mesh | Cohort Studies | es_ES |
dc.subject.mesh | Europe | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | HIV Infections | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Models, Statistical | es_ES |
dc.subject.mesh | Mortality | es_ES |
dc.subject.mesh | Risk Factors | es_ES |
dc.title | Parameter estimates for trends and patterns of excess mortality among persons on antiretroviral therapy in high-income European settings. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 31800404 | es_ES |
dc.format.volume | 33 Suppl 3 | es_ES |
dc.format.page | S271-S281 | es_ES |
dc.identifier.doi | 10.1097/QAD.0000000000002387 | es_ES |
dc.contributor.funder | Medical Research Council (Reino Unido) | |
dc.contributor.funder | Department for International Development (Reino Unido) | |
dc.contributor.funder | NIH - National Institute on Alcohol Abuse and Alcoholism (NIAAA) (Estados Unidos) | |
dc.contributor.funder | National Institute for Health Research (Reino Unido) | |
dc.contributor.funder | Unión Europea | |
dc.contributor.funder | Agence Nationale de Recherches sur le sida et les hépatites virales (Francia) | |
dc.contributor.funder | Institut National de la Santé et de la Recherche Médicale (Francia) | |
dc.contributor.funder | Ministero della Salute (Italia) | |
dc.contributor.funder | Ministerio de Sanidad y Consumo (España) | |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | |
dc.contributor.funder | Red de Investigación Cooperativa en Investigación en Sida (España) | |
dc.contributor.funder | Swiss National Science Foundation | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1473-5571 | |
dc.relation.publisherversion | http://dx.doi.org/10.1097/QAD.0000000000002387 | es_ES |
dc.identifier.journal | AIDS (London, England) | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/260694 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RETIC/RD06/006 | es_ES |
dc.rights.accessRights | open access | es_ES |