Show simple item record

dc.contributor.authorRomero-Becerra, Rafael
dc.contributor.authorSantamans, Ayelen M 
dc.contributor.authorFolgueira, Cintia
dc.contributor.authorSabio, Guadalupe
dc.identifier.citationInt J Mol Sci. 2020; 21(19):e7412es_ES
dc.description.abstractThe p38 mitogen-activated kinase (MAPK) family controls cell adaptation to stress stimuli. p38 function has been studied in depth in relation to cardiac development and function. The first isoform demonstrated to play an important role in cardiac development was p38α; however, all p38 family members are now known to collaborate in different aspects of cardiomyocyte differentiation and growth. p38 family members have been proposed to have protective and deleterious actions in the stressed myocardium, with the outcome of their action in part dependent on the model system under study and the identity of the activated p38 family member. Most studies to date have been performed with inhibitors that are not isoform-specific, and, consequently, knowledge remains very limited about how the different p38s control cardiac physiology and respond to cardiac stress. In this review, we summarize the current understanding of the role of the p38 pathway in cardiac physiology and discuss recent advances in the field.es_ES
dc.description.sponsorshipThis research was funded by the following grants to G.S: European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n◦ ERC 260464, EFSD/Lilly European Diabetes Research Programme Dr Sabio, 2017 Leonardo Grant for Researchers and Cultural Creators, BBVA Foundation (Investigadores-BBVA-2017) IN [17]_BBM_BAS_0066, MINECO-FEDER SAF2016-79126-R, PID2019-104399RB-I00, EUIN2017-85875, Comunidad de Madrid IMMUNOTHERCAN-CM S2010/BMD-2326 and B2017/BMD-3733, Fundación AECC and intramural grant 12-2016 IGP. R.R-B and A.M.S are fellows of the FPU (FPU17/03847) and FPI Severo Ochoa CNIC program (BES-2016-077635), respectively. C.F has a Sara Borrell contract (CD19/00078). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia, Innovación y Universidades (MCNU), and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).es_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.titlep38 MAPK Pathway in the Heart: New Insights in Health and Disease.es_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderUnión Europea. Comisión Europea 
dc.contributor.funderFundación BBVA 
dc.contributor.funderComunidad de Madrid (España) 
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España) 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderAsociación Española Contra el Cáncer 
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderFundación ProCNIC 
dc.identifier.journalInternational journal of molecular scienceses_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Papel de las quinasas activadas por el estrés en el desarrollo de enfermedades cardiovasculares, diabetes y cánceres_ES
dc.rights.accessRightsopen accesses_ES

Files in this item

Acceso Abierto

This item appears in the following Collection(s)

Show simple item record

Atribución 4.0 Internacional
This item is licensed under a: Atribución 4.0 Internacional