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dc.contributor.authorRomero-Becerra, Rafael
dc.contributor.authorSantamans, Ayelen M 
dc.contributor.authorFolgueira, Cintia
dc.contributor.authorSabio, Guadalupe 
dc.date.accessioned2020-10-26T09:03:10Z
dc.date.available2020-10-26T09:03:10Z
dc.date.issued2020-10-08
dc.identifier.citationInt J Mol Sci. 2020; 21(19):e7412es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/11195
dc.description.abstractThe p38 mitogen-activated kinase (MAPK) family controls cell adaptation to stress stimuli. p38 function has been studied in depth in relation to cardiac development and function. The first isoform demonstrated to play an important role in cardiac development was p38α; however, all p38 family members are now known to collaborate in different aspects of cardiomyocyte differentiation and growth. p38 family members have been proposed to have protective and deleterious actions in the stressed myocardium, with the outcome of their action in part dependent on the model system under study and the identity of the activated p38 family member. Most studies to date have been performed with inhibitors that are not isoform-specific, and, consequently, knowledge remains very limited about how the different p38s control cardiac physiology and respond to cardiac stress. In this review, we summarize the current understanding of the role of the p38 pathway in cardiac physiology and discuss recent advances in the field.es_ES
dc.description.sponsorshipThis research was funded by the following grants to G.S: European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n◦ ERC 260464, EFSD/Lilly European Diabetes Research Programme Dr Sabio, 2017 Leonardo Grant for Researchers and Cultural Creators, BBVA Foundation (Investigadores-BBVA-2017) IN [17]_BBM_BAS_0066, MINECO-FEDER SAF2016-79126-R, PID2019-104399RB-I00, EUIN2017-85875, Comunidad de Madrid IMMUNOTHERCAN-CM S2010/BMD-2326 and B2017/BMD-3733, Fundación AECC and intramural grant 12-2016 IGP. R.R-B and A.M.S are fellows of the FPU (FPU17/03847) and FPI Severo Ochoa CNIC program (BES-2016-077635), respectively. C.F has a Sara Borrell contract (CD19/00078). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia, Innovación y Universidades (MCNU), and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titlep38 MAPK Pathway in the Heart: New Insights in Health and Disease.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID33049962es_ES
dc.format.volume21es_ES
dc.format.number19es_ES
dc.identifier.doi10.3390/ijms21197412es_ES
dc.contributor.funderEuropean Commission
dc.contributor.funderFundación BBVA
dc.contributor.funderComunidad de Madrid
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)
dc.contributor.funderFundación Científica AECC
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.contributor.funderFundación ProCNIC
dc.description.peerreviewedes_ES
dc.identifier.e-issn1422-0067es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/ijms21197412es_ES
dc.identifier.journalInternational journal of molecular scienceses_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Papel de las quinasas activadas por el estrés en el desarrollo de enfermedades cardiovasculares, diabetes y cánceres_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/260464es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2016-79126-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PID2019-104399RB-I00es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BES-2016-077635es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/FPU17/03847es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CD19/00078es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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