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dc.contributor.author | Romero-Becerra, Rafael | |
dc.contributor.author | Santamans, Ayelen M | |
dc.contributor.author | Folgueira, Cintia | |
dc.contributor.author | Sabio, Guadalupe | |
dc.date.accessioned | 2020-10-26T09:03:10Z | |
dc.date.available | 2020-10-26T09:03:10Z | |
dc.date.issued | 2020-10-08 | |
dc.identifier.citation | Int J Mol Sci. 2020; 21(19):e7412 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/11195 | |
dc.description.abstract | The p38 mitogen-activated kinase (MAPK) family controls cell adaptation to stress stimuli. p38 function has been studied in depth in relation to cardiac development and function. The first isoform demonstrated to play an important role in cardiac development was p38α; however, all p38 family members are now known to collaborate in different aspects of cardiomyocyte differentiation and growth. p38 family members have been proposed to have protective and deleterious actions in the stressed myocardium, with the outcome of their action in part dependent on the model system under study and the identity of the activated p38 family member. Most studies to date have been performed with inhibitors that are not isoform-specific, and, consequently, knowledge remains very limited about how the different p38s control cardiac physiology and respond to cardiac stress. In this review, we summarize the current understanding of the role of the p38 pathway in cardiac physiology and discuss recent advances in the field. | es_ES |
dc.description.sponsorship | This research was funded by the following grants to G.S: European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n◦ ERC 260464, EFSD/Lilly European Diabetes Research Programme Dr Sabio, 2017 Leonardo Grant for Researchers and Cultural Creators, BBVA Foundation (Investigadores-BBVA-2017) IN [17]_BBM_BAS_0066, MINECO-FEDER SAF2016-79126-R, PID2019-104399RB-I00, EUIN2017-85875, Comunidad de Madrid IMMUNOTHERCAN-CM S2010/BMD-2326 and B2017/BMD-3733, Fundación AECC and intramural grant 12-2016 IGP. R.R-B and A.M.S are fellows of the FPU (FPU17/03847) and FPI Severo Ochoa CNIC program (BES-2016-077635), respectively. C.F has a Sara Borrell contract (CD19/00078). The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia, Innovación y Universidades (MCNU), and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | p38 MAPK Pathway in the Heart: New Insights in Health and Disease. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 33049962 | es_ES |
dc.format.volume | 21 | es_ES |
dc.format.number | 19 | es_ES |
dc.identifier.doi | 10.3390/ijms21197412 | es_ES |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Fundación BBVA | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Asociación Española Contra el Cáncer | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1422-0067 | es_ES |
dc.relation.publisherversion | https://doi.org/10.3390/ijms21197412 | es_ES |
dc.identifier.journal | International journal of molecular sciences | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Papel de las quinasas activadas por el estrés en el desarrollo de enfermedades cardiovasculares, diabetes y cáncer | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/260464 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2016-79126-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PID2019-104399RB-I00 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/BES-2016-077635 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/FPU17/03847 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CD19/00078 | es_ES |
dc.rights.accessRights | open access | es_ES |