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dc.contributor.authorSoriano-Arandes, Antoni
dc.contributor.authorFrick, Marie Antoinette
dc.contributor.authorGarcía López-Hortelano, Milagros
dc.contributor.authorSulleiro, Elena
dc.contributor.authorRodó, Carlota
dc.contributor.authorCabrera-Lafuente, Marta
dc.contributor.authorSuy, Anna
dc.contributor.authorDe la Calle, María
dc.contributor.authorSantos, Mar
dc.contributor.authorAntolin, Eugenia
dc.contributor.authorViñuela, María Del Carmen
dc.contributor.authorEspiau, María
dc.contributor.authorSalazar, Ainara
dc.contributor.authorGuarch-Ibáñez, Borja
dc.contributor.authorNavarro-Morón, Juan
dc.contributor.authorRamos-Amador, José-Tomás
dc.contributor.authorMartin-Nalda, Andrea
dc.contributor.authorDueñas, Eva
dc.contributor.authorBlázquez-Gamero, Daniel
dc.contributor.authorReques-Cosme, Resurrección
dc.contributor.authorOlabarrieta, Iciar
dc.contributor.authorPrieto, Luis
dc.contributor.authorThorne, Claire
dc.contributor.authorByrne, Thomas
dc.contributor.authorAdes, Anthony E
dc.contributor.authorRuiz-Burga, Elisa
dc.contributor.authorGiaquinto, Carlo
dc.contributor.authorMellado-Peña, María José
dc.contributor.authorGarcía-Alix, Alfredo
dc.contributor.authorCarreras, Elena
dc.contributor.authorSoler-Palacín, Pere
dc.contributor.authorSanchez, Marina P 
dc.contributor.authorVazquez, Ana 
dc.contributor.authorDe Ory, Fernando de
dc.identifier.citationPathogens. 2020 May 7;9(5):352.es_ES
dc.description.abstractZika virus (ZIKV) infection has been associated with congenital microcephaly and other neurodevelopmental abnormalities. There is little published research on the effect of maternal ZIKV infection in a non-endemic European region. We aimed to describe the outcomes of pregnant travelers diagnosed as ZIKV-infected in Spain, and their exposed children. This prospective observational cohort study of nine referral hospitals enrolled pregnant women (PW) who travelled to endemic areas during their pregnancy or the two previous months, or those whose sexual partners visited endemic areas in the previous 6 months. Infants of ZIKV-infected mothers were followed for about two years. ZIKV infection was diagnosed in 163 PW; 112 (70%) were asymptomatic and 24 (14.7%) were confirmed cases. Among 143 infants, 14 (9.8%) had adverse outcomes during follow-up; three had a congenital Zika syndrome (CZS), and 11 other potential Zika-related outcomes. The overall incidence of CZS was 2.1% (95%CI: 0.4-6.0%), but among infants born to ZIKV-confirmed mothers, this increased to 15.8% (95%CI: 3.4-39.6%). A nearly 10% overall risk of neurologic and hearing adverse outcomes was found in ZIKV-exposed children born to a ZIKV-infected traveler PW. Longer-term follow-up of these children is needed to assess whether there are any later-onset manifestations.es_ES
dc.description.sponsorshipThis work was supported by the European Union’s Horizon 2020 research and innovation programme under grant agreement No 734857 (ZIKAction).es_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.subject.meshZika viruses_ES
dc.subject.meshCongenital infectiones_ES
dc.subject.meshAdverse outcomees_ES
dc.titleClinical Outcomes of a Zika Virus Mother-Child Pair Cohort in Spaines_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderUnión Europea 
dc.identifier.journalPathogens (Basel, Switzerland)es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.rights.accessRightsopen accesses_ES

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