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dc.contributor.authorSalgüero Fernández, Sergio 
dc.contributor.authorGonzález-García, Juan
dc.contributor.authorBerenguer, Juan
dc.contributor.authorMontes, María L
dc.contributor.authorDiéz, Cristina
dc.contributor.authorLlop-Herrera, Elba
dc.contributor.authorPérez-Latorre, Leire
dc.contributor.authorBellóno, José María
dc.contributor.authorMedrano, Luz Maria 
dc.contributor.authorGarcia-Broncano, Pilar 
dc.contributor.authorJimenez-Sousa, Maria Angeles 
dc.contributor.authorResino, Salvador
dc.identifier.citationSci Rep . 2020 Jun 25;10(1):10384.es_ES
dc.description.abstractWe aimed to evaluate the association of plasma biomarkers linked to inflammation (bacterial translocation, inflammatory response, and endothelial dysfunction), coagulopathy, and angiogenesis with the severity of liver cirrhosis (assessed by the Child-Pugh-Turcotte score, CTP) and Child-Pugh B cirrhosis (CTP 7-9) in patients with advanced hepatitis C virus (HCV)-related cirrhosis. We carried out a cross-sectional study in 97 patients with advanced HCV-related cirrhosis (32 HCV-monoinfected and 65 HIV/HCV-coinfected). Plasma biomarkers were measured by ProcartaPlex multiplex immunoassays. The outcome variable was the CTP score and the Child-Pugh B cirrhosis (CTP 7-9). HIV/HCV-coinfected patients and HCV-monoinfected patients with advanced HCV-related cirrhosis had near-equivalent values of plasma biomarkers. Higher values of plasma biomarkers linked to an inflammatory response (IP-10, IL-8, IL-6, and OPG), endothelial dysfunction (sVCAM-1 and sICAM-1), and coagulopathy (D-dimer) were related to higher CTP values. The most significant biomarkers to detect the presence of Child-Pugh B cirrhosis (CTP 7-9) were IP-10 (p-value= 0.008) and IL-6 (p-value=0.002). The AUC-ROC values of IP-10, IL-6, and both biomarkers combined (IP-10+IL-6) were 0.78, 0.88, and 0.96, respectively. In conclusion, HIV infection does not appear to have a significant impact on the analyzed plasma biomarkers in patients with advanced HCV-related cirrhosis. However, plasma biomarkers linked to inflammation (inflammatory response and endothelial dysfunction) were related to the severity of liver cirrhosis (CTP score), mainly IP-10 and IL-6, which discriminated patients with Child-Pugh B concerning Child-Pugh A.es_ES
dc.description.sponsorshipThe HIV BioBank, is supported by Instituto de Salud Carlos III, Spanish Health Ministry (Grant n° RD06/0006/0035, RD12/0017/0037 and RD16/0025/0019) as part of the Plan Nacional R + D + I and cofinanced by ISCIII- Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER)”. The RIS Cohort (CoRIS) is funded by the Instituto de Salud Carlos III through the Red Temática de Investigación Cooperativa en SIDA (RIS C03/173, RD12/0017/0018 and RD16/0002/0006) as part of the Plan Nacional R + D + I and co-financed by ISCIII-Subdirección General de Evaluacion y e Fondo Europeo de Desarrollo Regional (FEDER). This study was supported by grants from Instituto de Salud Carlos III (ISCII; grant numbers PI14/01094 and PI17/00657 to JB, PI14/01581 and PI17/00903 to JGG, CP17CIII/00007 and PI18CIII/00028 to MAJS, and PI14CIII/00011 and PI17CIII/00003 to SR). The study was also funded by the RD16CIII/0002/0002, RD16/0025/0017, and RD16/0025/0018 projects as part of the Plan Nacional R + D + I and co-funded by ISCIII- Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER). JB is an investigator from the Programa de Intensificación de la Actividad Investigadora en el Sistema Nacional de Salud (I3SNS), Refs INT15/00079 and INT16/00100.es_ES
dc.publisherNature Researches_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subjectnfectious diseaseses_ES
dc.subjectInnate immunityes_ES
dc.subjectHIV infectionses_ES
dc.subjectViral infectiones_ES
dc.titlePlasma IP-10 and IL-6 are linked to Child-Pugh B cirrhosis in patients with advanced HCV-related cirrhosis: a cross-sectional study.es_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)
dc.contributor.funderRed Temática Cooperativa de Investigación en Sida (España)
dc.identifier.journalScientific reportses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RD06 / 0006/0035es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RD12 / 0017/0037es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RD16 / 0025/0019es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RIS C03 / 173es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RD12 / 0017/0018es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RD16 / 0002/0006es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI14 / 01094es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI17 / 00657es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/ PI14 / 01581es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI17 / 00903es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/CP17CIII / 00007es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI18CIII / 00028es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI14CIII / 00011es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/PI17CIII / 00003es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RD16CIII / 0002/0002es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RD16 / 0025/0017es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/RD16 / 0025/0018es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/INT15 / 00079es_ES
dc.relation.projectIDinfo:eu_repo/grantAgreement/ES/INT16 / 00100es_ES

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Atribución 4.0 Internacional
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