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dc.contributor.author | Delgado, Irene | |
dc.contributor.author | López-Delgado, Alejandra C | |
dc.contributor.author | Roselló-Díez, Alberto | |
dc.contributor.author | Giovinazzo, Giovanna | |
dc.contributor.author | Cadenas, Vanessa | |
dc.contributor.author | Fernandez-de-Manuel, Laura | |
dc.contributor.author | Sanchez-Cabo, Fatima | |
dc.contributor.author | Anderson, Matthew J | |
dc.contributor.author | Lewandoski, Mark | |
dc.contributor.author | Torres, Miguel | |
dc.date.accessioned | 2020-07-08T11:45:03Z | |
dc.date.available | 2020-07-08T11:45:03Z | |
dc.date.issued | 2020-06 | |
dc.identifier.citation | Sci Adv. 2020; 6(23):eaaz0742 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/10720 | |
dc.description.abstract | The positional information theory proposes that a coordinate system provides information to embryonic cells about their position and orientation along a patterning axis. Cells interpret this information to produce the appropriate pattern. During development, morphogens and interpreter transcription factors provide this information. We report a gradient of Meis homeodomain transcription factors along the mouse limb bud proximo-distal (PD) axis antiparallel to and shaped by the inhibitory action of distal fibroblast growth factor (FGF). Elimination of Meis results in premature limb distalization and HoxA expression, proximalization of PD segmental borders, and phocomelia. Our results show that Meis transcription factors interpret FGF signaling to convey positional information along the limb bud PD axis. These findings establish a new model for the generation of PD identities in the vertebrate limb and provide a molecular basis for the interpretation of FGF signal gradients during axial patterning. | es_ES |
dc.description.sponsorship | This study was supported by PGC2018-096486-B-I00 from the Spanish Ministry of Science, Innovation and Universities; RD16/0011/0019 from Instituto de Salud Carlos III; and grant S2017/BMD 3875 from the Comunidad de Madrid. The CNIC is supported by the Ministerio de Ciencia, Innovación y Universidades and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Association for the Advancement of Science (AAAS) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Proximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb. | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 32537491 | es_ES |
dc.format.volume | 6 | es_ES |
dc.format.number | 23 | es_ES |
dc.format.page | eaaz0742 | es_ES |
dc.identifier.doi | 10.1126/sciadv.aaz0742 | es_ES |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2375-2548 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1126/sciadv.aaz0742 | es_ES |
dc.identifier.journal | Science advances | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Control Genético del Desarrollo y Regeneración de Órganos | es_ES |
dc.repisalud.orgCNIC | CNIC::Unidades técnicas::Bioinformática | es_ES |
dc.repisalud.orgCNIC | CNIC::Unidades técnicas::Células Pluripotentes | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PGC2018-096486-B-I00 | es_ES |
dc.rights.accessRights | open access | es_ES |
dc.relation.projectFECYT | info:eu-repo/grantAgreement/MINECO//RD16%2F0011%2F0019/ES/Red de Terapia Celular (TerCel)/ |