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dc.contributor.authorDelgado, Irene 
dc.contributor.authorLópez-Delgado, Alejandra C
dc.contributor.authorRoselló-Díez, Alberto
dc.contributor.authorGiovinazzo, Giovanna 
dc.contributor.authorCadenas, Vanessa
dc.contributor.authorFernandez-de-Manuel, Laura 
dc.contributor.authorSanchez-Cabo, Fatima 
dc.contributor.authorAnderson, Matthew J
dc.contributor.authorLewandoski, Mark
dc.contributor.authorTorres, Miguel 
dc.date.accessioned2020-07-08T11:45:03Z
dc.date.available2020-07-08T11:45:03Z
dc.date.issued2020-06
dc.identifier.citationSci Adv. 2020; 6(23):eaaz0742es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/10720
dc.description.abstractThe positional information theory proposes that a coordinate system provides information to embryonic cells about their position and orientation along a patterning axis. Cells interpret this information to produce the appropriate pattern. During development, morphogens and interpreter transcription factors provide this information. We report a gradient of Meis homeodomain transcription factors along the mouse limb bud proximo-distal (PD) axis antiparallel to and shaped by the inhibitory action of distal fibroblast growth factor (FGF). Elimination of Meis results in premature limb distalization and HoxA expression, proximalization of PD segmental borders, and phocomelia. Our results show that Meis transcription factors interpret FGF signaling to convey positional information along the limb bud PD axis. These findings establish a new model for the generation of PD identities in the vertebrate limb and provide a molecular basis for the interpretation of FGF signal gradients during axial patterning.es_ES
dc.description.sponsorshipThis study was supported by PGC2018-096486-B-I00 from the Spanish Ministry of Science, Innovation and Universities; RD16/0011/0019 from Instituto de Salud Carlos III; and grant S2017/BMD 3875 from the Comunidad de Madrid. The CNIC is supported by the Ministerio de Ciencia, Innovación y Universidades and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505).es_ES
dc.language.isoenges_ES
dc.publisherAmerican Association for the Advancement of Sciencees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleProximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb.es_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID32537491es_ES
dc.format.volume6es_ES
dc.format.number23es_ES
dc.format.pageeaaz0742es_ES
dc.identifier.doi10.1126/sciadv.aaz0742es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderComunidad de Madrides_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2375-2548es_ES
dc.relation.publisherversionhttps://doi.org/10.1126/sciadv.aaz0742es_ES
dc.identifier.journalScience advanceses_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Control Genético del Desarrollo y Regeneración de Órganoses_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Bioinformáticaes_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Células Pluripotenteses_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PGC2018-096486-B-I00es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16/0011/0019es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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