Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/10720
Título
Proximo-distal positional information encoded by an Fgf-regulated gradient of homeodomain transcription factors in the vertebrate limb.
Autor(es)
Delgado, Irene CNIC | López-Delgado, Alejandra C | Roselló-Díez, Alberto | Giovinazzo, Giovanna CNIC | Cadenas, Vanessa | Fernandez-de-Manuel, Laura CNIC | Sanchez-Cabo, Fatima CNIC | Anderson, Matthew J | Lewandoski, Mark | Torres, Miguel CNIC
Fecha de publicación
2020-06
Cita
Sci Adv. 2020; 6(23):eaaz0742
Idioma
Inglés
Tipo de documento
journal article
Resumen
The positional information theory proposes that a coordinate system provides information to embryonic cells about their position and orientation along a patterning axis. Cells interpret this information to produce the appropriate pattern. During development, morphogens and interpreter transcription factors provide this information. We report a gradient of Meis homeodomain transcription factors along the mouse limb bud proximo-distal (PD) axis antiparallel to and shaped by the inhibitory action of distal fibroblast growth factor (FGF). Elimination of Meis results in premature limb distalization and HoxA expression, proximalization of PD segmental borders, and phocomelia. Our results show that Meis transcription factors interpret FGF signaling to convey positional information along the limb bud PD axis. These findings establish a new model for the generation of PD identities in the vertebrate limb and provide a molecular basis for the interpretation of FGF signal gradients during axial patterning.
Versión en línea
DOI
Aparece en las colecciones
Ficheros en el ítem
- Nombre:
- ProximoDistalPositionalInforma ...
- Tamaño:
- 5.441Mb
- Formato:
- Descripción:
- Artículo